The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges

Radomska, Anna; Leszczyszyn, Jarosław; Radomski, Marek W.

doi:10.17219/acem/60879

Cited by 70 publications

(36 citation statements)

References 46 publications

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“…Nanomaterials have different chemical, physical, and biological characteristics compared to larger materials of the same chemical composition. They are now being used widely in biomedical and many industrial applications [1–3]. However, widespread use of nanomaterials may lead to environmental contamination and human exposure by inhalation, dermal and oral routes, raising concerns about their potential toxicity [3].…”

Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Nemmar

Yuvaraju

Beegam

et al. 2017

Oxidative Medicine and Cellular Longevity

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CeO2 nanoparticles (CeO2 NPs) which are used as a diesel fuel additive are emitted in the particulate phase in the exhaust, posing a health concern. However, limited information exists regarding the in vivo acute toxicity of CeO2 NPs on multiple organs. Presently, we investigated the acute (24 h) effects of intratracheally instilled CeO2 NPs in mice (0.5 mg/kg) on oxidative stress, inflammation, and DNA damage in major organs including lung, heart, liver, kidneys, spleen, and brain. Lipid peroxidation measured by malondialdehyde production was increased in the lungs only, and reactive oxygen species were increased in the lung, heart, kidney, and brain. Superoxide dismutase activity was decreased in the lung, liver, and kidney, whereas glutathione increased in lung but it decreased in the kidney. Total nitric oxide was increased in the lung and spleen but it decreased in the heart. Tumour necrosis factor-α increased in all organs studied. Interleukin- (IL-) 6 increased in the lung, heart, liver, kidney, and spleen. IL-1β augmented in the lung, heart, kidney, and spleen. Moreover, CeO2 NPs induced DNA damage, assessed by COMET assay, in all organs studied. Collectively, these findings indicate that pulmonary exposure to CeO2 NPs causes oxidative stress, inflammation, and DNA damage in multiple organs.

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Section: Introductionmentioning

confidence: 99%

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Nemmar

Yuvaraju

Beegam

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…There were recorded extensive efforts to develop effective nanomaterials as diagnostic, prevention and treatment tools for cancer and other disorders, such as infectious, cardiovascular, and central nervous system diseases (Zdrojewicz et al, 2015; Radomska et al, 2016; Torres-Sangiao et al, 2016). The interest for the liaison between nanoparticles and medicine could be quantified by the number of articles enlisted in the PubMed database—over 130,000 at the moment that this article was written (November 2016), number acquired after a search for “nanoparticles.”…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile

et al. 2017

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The use of magnetic iron oxide nanoparticles in biomedicine has evolved intensely in the recent years due to the multiple applications of these nanomaterials, mainly in domains like cancer. The aim of the present study was: (i) to develop biocompatible colloidal suspensions based on magnetic iron oxide nanoparticles as future theranostic tools for skin pathology and (ii) to test their effects in vitro on human keratinocytes (HaCat cells) and in vivo by employing an animal model of acute dermal toxicity. Biocompatible colloidal suspensions were obtained by coating the magnetic iron oxide nanoparticles resulted during the solution combustion synthesis with a double layer of oleic acid, as innovative procedure in increasing bioavailability. The colloidal suspensions were characterized in terms of dynamic light scattering (DLS) and transmission electron microscopy (TEM). The in vitro effects of these suspensions were tested by means of Alamar blue assay and the noxious effects at skin level were measured using non-invasive methods. The in vitro results indicated a lack of toxicity on normal human cells induced by the iron oxide nanoparticles colloidal suspensions after an exposure of 24 h to different concentrations (5, 10, and 25 μg·mL−1). The dermal acute toxicity test showed that the topical applications of the colloidal suspensions on female and male SKH-1 hairless mice were not associated with significant changes in the quality of barrier skin function.

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“…[1][2][3] Accidental or involuntary contact during production or use of nanoparticles (NPs) may occur via various routes such as inhalation, ingestion, or skin penetration. 3,4 Actually, the potential of NPs to pass across the alveolar-capillary barrier and to reach the circulating blood and thus have access to other organs is a reason for disquiet.…”

Section: Introductionmentioning

confidence: 99%

The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice

Al-Salam¹,

Beegam²,

Yuvaraju³

et al. 2017

IJN

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Cerium oxide nanoparticles (CeO 2 NPs), used as a diesel fuel catalyst, can be emitted into the ambient air, resulting in exposure to humans by inhalation. Recent studies have reported the development of lung toxicity after pulmonary exposure to CeO 2 NPs. However, little is known about the possible thrombotic effects of these NPs. The present study investigated the acute (24 hours) effect of intratracheal (IT) instillation of either CeO 2 NPs (0.1 or 0.5 mg/kg) or saline (control) on pulmonary and systemic inflammation and oxidative stress and thrombosis in mice. CeO 2 NPs induced a significant increase of neutrophils into the bronchoalveolar lavage (BAL) fluid with an elevation of tumor necrosis factor α (TNFα) and a decrease in the activity of the antioxidant catalase. Lung sections of mice exposed to CeO 2 NPs showed a dose-dependent infiltration of inflammatory cells consisting of macrophages and neutrophils. Similarly, the plasma levels of C-reactive protein and TNFα were significantly increased, whereas the activities of catalase and total antioxidant were significantly decreased. Interestingly, CeO 2 NPs significantly and dose dependently induced a shortening of the thrombotic occlusion time in pial arterioles and venules. Moreover, the plasma concentrations of fibrinogen and plasminogen activator inhibitor-1 were significantly elevated by CeO 2 NPs. The direct addition of CeO 2 NPs (1, 5, or 25 μg/mL) to mouse whole blood, collected from the inferior vena cava, in vitro neither caused significant platelet aggregation nor affected prothrombin time or partial thromboplastin time, suggesting that the thrombotic events observed in vivo may have resulted from systemic inflammation and/or oxidative stress induced by CeO 2 NPs. This study concludes that acute pulmonary exposure to CeO 2 NPs induces pulmonary and systemic inflammation and oxidative stress and promotes thrombosis in vivo.

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The Nanopharmacology and Nanotoxicology of Nanomaterials: New Opportunities and Challenges

Cited by 70 publications

References 46 publications

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile

The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice

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