Abstract:In Vibrio cholerae, the master regulator FlrA controls transcription of downstream flagellar genes in a σ54‐dependent manner. However, the molecular basis of regulation by VcFlrA, which contains a phosphorylation‐deficient N‐terminal FleQ domain, has remained elusive. Our studies on VcFlrA, four of its constructs, and a mutant showed that the AAA+ domain of VcFlrA, with or without the linker ‘L’, remains in ATPase‐deficient monomeric states. By contrast, the FleQ domain plays a pivotal role in promoting higher… Show more
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