The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment
Hannah Wapenaar,
Gillian Clifford,
Willow Rolls
et al.
Abstract:DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns. However, the mechanisms underlying DNMT3A recruitment to and function within different chromatin environments remain unclear. Using a combination of biochemical and structural approaches we find that DNMT3A interacts using multiple interfaces with chromatin; directly binding generic nucleosome features as well as site-specific post-translational histone modifications. The N-terminal region, unique … Show more
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