The myriad roles of RNA structure in the flavivirus life cycle
Quinn H. Abram,
Breanna N. Landry,
Alex B. Wang
et al.
Abstract:As positive-sense RNA viruses, the genomes of flaviviruses serve as the template for all stages of the viral life cycle, including translation, replication, and infectious particle production. Yet, they encode just 10 proteins, suggesting that the structure and dynamics of the viral RNA itself helps shepherd the viral genome through these stages. Herein, we highlight advances in our understanding of flavivirus RNA structural elements through the lens of their impact on the viral life cycle. We highlight how RN… Show more
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