2011
DOI: 10.1016/j.ejcts.2010.12.052
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The myocardial protective effects of adenosine pretreatment in children undergoing cardiac surgery: a randomized controlled clinical trial

Abstract: This study demonstrates that adenosine pretreatment is protective of the myocardium during open-heart surgery in pediatric patients.

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Cited by 23 publications
(12 citation statements)
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“…Many studies have implicated activation of calcineurin in I/R damage in neurons [50, 51], lung [52], kidney [53], and heart [5457]. Pharmacological studies using cyclosporine A (CsA) to inhibit calcineurin need to be interpreted with caution because CsA also inhibits the mitochondrial permeability transition pore (MPTP) in a calcineurin-independent fashion and MPTP is an important component of the cascade through which I/R damage occurs [58].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Many studies have implicated activation of calcineurin in I/R damage in neurons [50, 51], lung [52], kidney [53], and heart [5457]. Pharmacological studies using cyclosporine A (CsA) to inhibit calcineurin need to be interpreted with caution because CsA also inhibits the mitochondrial permeability transition pore (MPTP) in a calcineurin-independent fashion and MPTP is an important component of the cascade through which I/R damage occurs [58].…”
Section: Discussionmentioning
confidence: 99%
“…Pharmacological studies using cyclosporine A (CsA) to inhibit calcineurin need to be interpreted with caution because CsA also inhibits the mitochondrial permeability transition pore (MPTP) in a calcineurin-independent fashion and MPTP is an important component of the cascade through which I/R damage occurs [58]. However, FK506, does not inhibit MPTP and has also been shown to be cardioprotective in rat models of I/R [5457, 59]. Our studies would suggest there are time of day differences in the activation of calcineurin in response to I/R, however, we were not able to detect significant AM/PM differences in in vitro biochemical assays of total calcineurin activity in heart tissue extracts (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…Studies of intravenous adenosine prior to and during heart surgery have been modest in both size and effect 166168 . Acadesine, a drug thought to increase adenosine levels in ischemic tissues, was compared with placebo in 2,698 patients undergoing CABG.…”
Section: Clinical Applications Of Pkc Regulatorsmentioning
confidence: 99%
“…A recent randomized trial looking at the effects of adenosine pretreatment in children undergoing cardiac surgery to repair congenital heart defects found that children in the adenosine group had less myocardial injury as shown by lower troponin levels, less inotropic requirements and shorter intensive care unit stays [46]. However, this trial was relatively small.…”
Section: Adenosinementioning
confidence: 96%