The Myeloproliferative Neoplasm Landscape: A Patient’s Eye View

Abstract

Patients with myeloproliferative neoplasms

Essential Thrombocythemia in a 15-Year-Old Female: Presentation, Workup, and Treatment Considerations in the Pediatric Population

“…This is a constitutively active mutation that activates the JAK/STAT signaling pathway leading to cellular proliferation. CALR and MPL are also driver mutations that activate the JAK/STAT pathway ( Kucine et al, 2014 ; Petruk & Mathias, 2020 ). This causes myeloproliferative neoplasms to develop: ET, polycythemia vera (PV), and PMF ( Vannucchi et al, 2017 ).…”

“…The symptoms assessed include fatigue, early satiety, abdominal discomfort, inactivity, difficulty concentrating, night sweats, pruritis, bone pain, fever, and unintentional weight loss. This can be used to assess treatment response and aid in identifying disease progression earlier ( Petruk & Mathias, 2020 ). Signs and symptoms that could indicate disease progression include splenomegaly, weight loss, night sweats, progressive leukocytosis, and thrombocytosis ( Agarwal et al, 2015 ).…”

A Cross-sectional Study of Patients and Physicians on the Impact of Myeloproliferative Neoplasms on Patient Health: The Landmark Survey From Taiwan

“…To improve the clinical outcomes and treatment satisfaction, greater participation of patients in decision-making is required ( 21 ). However, little is known about the understanding of patients with MPN regarding their disease and its impact on their lives.…”

Osteolytic lesion in polycythemia vera: First report and review of literature

“…The three most common MPNs are polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF). Patients with MPN can experience a constellation of debilitating symptoms that negatively impact their quality of life [2][3][4][5]. In prior surveys of patients with MPNs, bone pain was the fourth most common symptom reported by 44% of patients and rated as "very severe" in up to a third of MF patients [2][3][4][5].In very rare situations, patients with MPN can develop osteolytic lesions [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

“…Patients with MPN can experience a constellation of debilitating symptoms that negatively impact their quality of life [2][3][4][5]. In prior surveys of patients with MPNs, bone pain was the fourth most common symptom reported by 44% of patients and rated as "very severe" in up to a third of MF patients [2][3][4][5].In very rare situations, patients with MPN can develop osteolytic lesions [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. We report the first case of an osteolytic lesion in a chronic-phase PV patient, and review published case reports of MPN patients with osteolytic lesions to summarize the clinical characteristics and implications for patient care.…”