The myeloid derived suppressor cells: Who are they? Can they be used as a diagnostic tool to investigate metastasis in veterinary medicine?

Nadal, Clémence; Béguin, Jérémy; Benchekroun, Ghita; Roux, Delphine Le

doi:10.1016/j.cimid.2018.10.003

Cited by 2 publications

(4 citation statements)

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“…These populations can be isolated from the blood, spleen and secondary lymphoid organs, as well as the TME in both humans and dogs and their expansion is related to various types of cancer. [149][150][151] MDSCs are found in very low numbers in healthy individuals 152,153 and have been shown to expand under various pathological conditions, such as cancer, inflammation, trauma and sepsis in animals and humans. 153,154 In a study by Yang et al (2017), the total number of circulating MDSCs was higher in human bladder cancer patients, compared to healthy controls.…”

Section: Myeloid-derived Suppressor Cells (Mdscs)mentioning

confidence: 99%

“…Mechanistically, peroxynitrite induces nitration and nitrosylation of various amino acids, such as cysteine, methionine, tryptophan and tyrosine, leading to nitration of the TCR and an alteration in T-cell antigen recognition of the MHC-peptide complex. 152 The expansion of MDSCs in cancer relies on multiple factors, including granulocyte-macrophage colonystimulating factor (CSF), macrophage-CSF and granulocyte CSF, which stimulates the bone marrow to produce more MDSCs. 161,162 In addition, VEGF also plays a critical role in the expansion and recruitment of MDSCs within the TME, as well as IL-12, IL-13, chemokine (C-C motif) ligand 2 (CCL-2), C-X-C motif chemokine ligand 5 (CXCL-5) and C-X-C motif chemokine ligand 12 (CXCL-12).…”

Section: Myeloid-derived Suppressor Cells (Mdscs)mentioning

confidence: 99%

“…In recent studies, peroxynitrite, one of the most powerful oxidants, was reported to significantly contribute to the immunosuppressive activity of MDSCs. Mechanistically, peroxynitrite induces nitration and nitrosylation of various amino acids, such as cysteine, methionine, tryptophan and tyrosine, leading to nitration of the TCR and an alteration in T‐cell antigen recognition of the MHC‐peptide complex 152 …”

Section: Mechanisms Of Immune Surveillance In Bladder Cancermentioning

confidence: 99%

“…MDSCs are found in very low numbers in healthy individuals 152,153 and have been shown to expand under various pathological conditions, such as cancer, inflammation, trauma and sepsis in animals and humans 153,154 . In a study by Yang et al.…”

Section: Mechanisms Of Immune Surveillance In Bladder Cancermentioning

confidence: 99%

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Role of the tumour microenvironment in bladder cancer pathogenesis and value of the reverse translational approach: a tale of two species

Ahmed,

Zdyrski,

Cheville

et al. 2023

Clinical and Translational Dis

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BackgroundBladder cancer is a significant malignancy in humans and canines, with high death rates and devastating clinical symptoms. Despite significant advances in therapeutic management over the years, only a small fraction of bladder cancer patients respond to immunotherapies as a second line of treatment. Since immunotherapies act on various cellular and molecular targets in the bladder cancer tumour microenvironment (TME), a greater understanding of the various types of immune cells, immune checkpoint molecules and cytokines involved in antitumour immunity will help to improve the success rate of current and novel immunotherapies, therefore enhancing the patients quality of life. Accumulating evidence shows fundamental similarities between human and canine muscle‐invasive bladder cancer (MIBC) in their clinical, histological and molecular features.AimThis review focuses on comparative aspects of MIBC in both species, highlighting the role that canines can play as a model for studying MIBC. Additionally, we discuss the various types of immune cells within bladder cancer TME that can influence the prognosis and response to immunotherapy and chemotherapy in both species.ConclusionIt remains challenging to recapitulate the heterogeneity and complexity of the bladder cancer tumour microenvironment using in vivo and in vitro models, such as zebrafish and 3D organoids models. Optimization of these techniques to create a more representative translational model has been facilitated through in vitro immune‐oncology cocultures, which are considered promising tools to help select the ideal individualized treatment options and predict disease prognosis.

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