The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways

Liu, Jianhua; Chen, Chuang; Li, Ze‐Yang; Zou, Zhimiao; Gao, Dongcheng; Zhang, Xue; Kuang, Xinwen; Sun, Zhihong; Zheng, Weijie; Zhou, Ping; Sun, Shengrong

doi:10.1016/j.yexcr.2020.112157

Cited by 15 publications

(17 citation statements)

References 47 publications

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“…MyD88 is well-known as an intracellular adaptor protein of TLRs that plays a critical role in connecting TLRs and intracellular proteins to transmit signals from TLRs. Since TLRs-mediated signaling is closely involved in the progression of various diseases, the MyD88 protein has been targeted as a therapeutic target and, actually, several MyD88 inhibitors have been developed to treat inflammation-related diseases such as atherosclerosis, cancer, and leukaemia ( Chen et al, 2019 ; Liu et al, 2020 ; Shiratori et al, 2017 ). Therefore, the results of our comparative study strongly support that HMS could effectively inhibit E. faecalis -mediated inflammatory responses in HT-29 cells.…”

Section: Discussionmentioning

confidence: 99%

Hovenia Monofloral Honey can Attenuate Enterococcus faecalis Mediated Biofilm Formation and Inflammation

You¹,

Woo²,

Lee³

2022

Food Sci Anim Resour

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Section: Discussionmentioning

confidence: 99%

Hovenia Monofloral Honey can Attenuate Enterococcus faecalis Mediated Biofilm Formation and Inflammation

You¹,

Woo²,

Lee³

2022

Food Sci Anim Resour

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“…The dose-dependent effects of DOX and MNs-PEG/IR780-DOX on 4T1-luc cells viability were determined with Cell Counting Kit 8 (CCK-8) assay (Dojindo) according to the manufacturer’s instructions. 25 4T1-luc cells were plated in a 96-well cell culture plate at a concentration of 1 × 10 4 cells per well and incubated with concentrations of MNs-PEG/IR780-DOX ranging from 0.007813 to 32 µg/mL. The exact amounts of free DOX were added to parallel wells as controls.…”

Section: Methodsmentioning

confidence: 99%

In situ Injection of pH- and Temperature-Sensitive Nanomaterials Increases Chemo-Photothermal Efficacy by Alleviating the Tumor Immunosuppressive Microenvironment

Liu¹,

Guo²,

Yan³

et al. 2022

IJN

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Purpose Triple-negative breast cancer (TNBC) is challenging to treat with traditional “standard of care” therapy due to the lack of targetable biomarkers and rapid progression to distant metastasis. Methods We synthesized a novel combination regimen that included chemotherapy and photothermal therapy (PTT) to address this problem. Here, we tested a magnetic nanosystem (MNs-PEG/IR780-DOX micelles) loaded with the near-infrared (NIR) photothermal agent IR780 and doxorubicin (DOX) to achieve chemo-photothermal and boost antitumor immunity. Intraductal (i.duc) administration of MNs-PEG/IR780-DOX could increase the concentration of the drug in the tumor while reducing systemic side effects. Results We showed more uptake of MNs-PEG/IR780-DOX by 4T1-luc cells and higher penetration in the tumor. MNs-PEG/IR780-DOX exhibited excellent photothermal conversion in vivo and in vitro. The release of DOX from MNs-PEG/IR780-DOX is pH- and temperature-sensitive. Facilitated by i.duc administration, MNs-PEG/IR780-DOX displayed antitumor effects and prevented distant organs metastasis under NIR laser (L) irradiation and magnetic field (MF)while avoiding DOX-induced toxicity. More importantly, MNs-PEG/IR780-DOX alleviated tumor immunosuppressive microenvironment by increasing tumor CD8 + T cells infiltration and reducing the proportion of myeloid-derived suppressor cells (MDSCs) and Tregs. Conclusion Intraductal administration of pH- and temperature-sensitive MNs-PEG/IR780-DOX with L and MF had the potential for achieving minimally invasive, targeted, and accurate treatment of TNBC.

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“…On the other hand, Pax‐5 functions as a potential tumor‐suppressor factor and inhibits NF‐κB signaling via downregulating IKKε, resulting in EMT inhibition and decreased metastasis of breast cancer cells (Harquail et al, 2018). Sinomenine and TJ‐M2010‐2 as MyD88 inhibitor have been utilized to suppress NF‐κB/EMT axis in interrupting breast cancer metastasis (J. H. Liu et al, 2020; Song et al, 2015). More experiments are required to reveal the role of NF‐κB/EMT axis in the progression of breast tumor cells (H. Xu et al, 2017).…”

Section: Nf‐κb and Emt Interaction In Various Cancersmentioning

confidence: 99%

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Mirzaei

Saghari

Bassiri

et al. 2022

Journal Cellular Physiology

104

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Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) is a well‐known mechanism responsible for the invasiveness of tumor cells. A number of molecular pathways can regulate the EMT mechanism in cancer cells and nuclear factor‐kappaB (NF‐κB) is one of them. The nuclear translocation of NF‐κB p65 can induce the transcription of several genes involved in EMT induction. The present review describes NF‐κB and EMT interaction in cancer cells and their association in cancer progression. Due to the oncogenic role NF‐κB signaling, its activation enhances metastasis of tumor cells via EMT induction. This has been confirmed in various cancers including brain, breast, lung and gastric cancers, among others. The ZEB1/2, transforming growth factor‐β, and Slug as inducers of EMT undergo upregulation by NF‐κB to promote metastasis of tumor cells. After EMT induction driven by NF‐κB, a significant decrease occurs in E‐cadherin levels, while N‐cadherin and vimentin levels undergo an increase. The noncoding RNAs can potentially also function as upstream mediators and modulate NF‐κB/EMT axis in cancers. Moreover, NF‐κB/EMT axis is involved in mediating drug resistance in tumor cells. Thus, suppressing NF‐κB/EMT axis can also promote the sensitivity of cancer cells to chemotherapeutic agents.

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The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways

Cited by 15 publications

References 47 publications

Hovenia Monofloral Honey can Attenuate Enterococcus faecalis Mediated Biofilm Formation and Inflammation

Hovenia Monofloral Honey can Attenuate Enterococcus faecalis Mediated Biofilm Formation and Inflammation

In situ Injection of pH- and Temperature-Sensitive Nanomaterials Increases Chemo-Photothermal Efficacy by Alleviating the Tumor Immunosuppressive Microenvironment

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

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