The mutagenic versus protective role of vitamin A on the induction of chromosomal aberration in human lymphocyte cultures

Badr, F. M.; El-Habit, Ola H.; Hamdy, Mostafa A.; Hassan, G.A.R

doi:10.1016/s1383-5718(98)00038-2

Cited by 23 publications

(9 citation statements)

References 26 publications

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“…Opposite findings have reported that increased risk of lung cancer can develop in smokers who receive antioxidants [21,22]. Excess amounts of Vitamin A have been found to increase chromosomal aberration in cultured lymphocytes [23]. Further, rats treated with retinol also experience higher incidence of pheochromocytomas [24].…”

Section: Discussionmentioning

confidence: 98%

Association of hepatitis virus infection, alcohol consumption and plasma vitamin A levels with urinary 8-hydroxydeoxyguanosine in chemical workers

Wong

Yeh

Hsueh

et al. 2003

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Discussionmentioning

confidence: 98%

Association of hepatitis virus infection, alcohol consumption and plasma vitamin A levels with urinary 8-hydroxydeoxyguanosine in chemical workers

Wong

Yeh

Hsueh

et al. 2003

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Similarly grape seed proanthocyanidin extract has also been reported to inhibit adriamycin-induced toxicity (Debasis et al, 2002). Similarly β-carotene and vitamin C have been reported to reduce the incidence of adriamycin-induced chromosomal damage (El-Nahas et al, 1993;Badr et al, 1998;Cabrera, 2000). Earlier it was shown that the extracts of Panax ginseng (You et al, 2005) tomato extract (Karimi et al, 2005) and Prunella vulgari (Psotova et al, 2005) protect normal cells against ADR-induced toxicity.…”

Section: Discussionmentioning

confidence: 98%

Effect of Terminalia arjuna extract on adriamycin‐induced DNA damage

Reddy¹,

Seshadri²,

Reddy³

et al. 2008

Phytotherapy Research

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The effect of a bark extract of Terminalia arjuna (TAE) was studied on the alteration of adriamycin (ADR)-induced micronuclei formation in cultured human peripheral blood lymphocytes. Exposure of lymphocytes to ADR resulted in a dose-dependent increase in the micronuclei formation indicating DNA damage. Pretreatment of lymphocytes with TAE before ADR treatment resulted in a significant decline in micronuclei formation. Increasing doses of ADR caused a dose-dependent increase in the frequency of lymphocytes bearing one, two and multiple micronuclei. Prior exposure of lymphocytes to 15 microg/mL of TAE significantly reduced the frequency of lymphocytes bearing one, two and multiple micronuclei when compared with ADR-treated control. TAE-inhibited the induction of (*)OH (hydroxyl), O2(*-) (superoxide), DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS(*+) (2,2-azino-bis-3-ethyl benzothiazoline-6-sulphonic acid) radicals in a dose-dependent manner. These results demonstrate that TAE protects DNA against ADR-induced damage.

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“…under particular conditions were clastogenic and cytotoxic and caused DNA breaks and sister chromatid exchanges [2,[21][22][23]. Badr et al [24] observed a proportional increase in the frequency of human lymphocytes with chromosomal aberrations with increase of dose of vitamin A in blood cultured for 48 h. The clastogenic action of VC probably arises from the H 2 O 2 resulting from the oxidation of vitamin C in the presence of oxygen and metal ions [9,25].…”

Section: Discussionmentioning

confidence: 99%

Protection and induction of chromosomal damage by vitamin C in human lymphocyte cultures

Antunes

Takahashi

1999

Teratog. Carcinog. Mutagen.

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Some chemotherapeutic approaches have proposed the use of antioxidants such as vitamin C (VC) to minimize the cytotoxicity and damage induced in normal tissue by antitumor agents that produce free radicals. Nevertheless, VC can also be cytotoxic, genotoxic, and harmful when combined with antitumor agents in human cells in vitro. The present study was undertaken to investigate the effects of VC (100, 200, 500, and 1,000 μg/ml) on human peripheral blood lymphocytes in vitro and its anticlastogenic effect on chromosomal aberrations induced by doxorubicin (DXR). VC did not show a clastogenic effect by itself, except at 1,000 μg/ml. At the concentration of 100 or 200 μg/ml of VC, administered in pre‐, post‐, or simultaneous treatment, there was a significant reduction in both chromosome aberrations and number of abnormal metaphases induced by DXR. At the doses of 500 or 1,000 μg/ml, VC did not present the same protective effect and was cytotoxic. Under the present experimental conditions, the efficiency of VC in protecting against chromosome damage was dependent on the doses used. Teratogenesis Carcinog. Mutagen. 19:53–59, 1999. © 1999 Wiley‐Liss, Inc.

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The mutagenic versus protective role of vitamin A on the induction of chromosomal aberration in human lymphocyte cultures

Cited by 23 publications

References 26 publications

Association of hepatitis virus infection, alcohol consumption and plasma vitamin A levels with urinary 8-hydroxydeoxyguanosine in chemical workers

Association of hepatitis virus infection, alcohol consumption and plasma vitamin A levels with urinary 8-hydroxydeoxyguanosine in chemical workers

Effect of Terminalia arjuna extract on adriamycin‐induced DNA damage

Protection and induction of chromosomal damage by vitamin C in human lymphocyte cultures

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