The multisensory regulation of unconventional T cell homeostasis

Darrigues, Julie; Almeida, Vicente Eduardo Soares de; Conti, Eller; Ribot, Julie C.

doi:10.1016/j.smim.2022.101657

Cited by 5 publications

(1 citation statement)

References 191 publications

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“…On one hand, ILTC, like innate immune cells, provide a rapid and effective first line of defense at host barrier sites to resist pathogen invasion. On the other hand, ILTC can trigger chronic inflammation, highlighting the importance of their homeostasis in maintaining tissue integrity (Darrigues et al, 2022).…”

Section: Innate-like T Lymphoid Cells/unconventional T Cellsmentioning

confidence: 99%

Advances in understanding immune homeostasis in latent tuberculosis infection

Niu,

Wang,

Luo

et al. 2024

WIREs Mechanisms of Disease

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Nearly one‐fourth of the global population is infected by Mycobacterium tuberculosis (Mtb), and approximately 90%–95% remain asymptomatic as latent tuberculosis infection (LTBI), an estimated 5%–10% of those with latent infections will eventually progress to active tuberculosis (ATB). Although it is widely accepted that LTBI transitioning to ATB results from a disruption of host immune balance and a weakening of protective immune responses, the exact underlying immunological mechanisms that promote this conversion are not well characterized. Thus, it is difficult to accurately predict tuberculosis (TB) progression in advance, leaving the LTBI population as a significant threat to TB prevention and control. This article systematically explores three aspects related to the immunoregulatory mechanisms and translational research about LTBI: (1) the distinct immunocytological characteristics of LTBI and ATB, (2) LTBI diagnostic markers discovery related to host anti‐TB immunity and metabolic pathways, and (3) vaccine development focus on LTBI.This article is categorized under: Infectious Diseases > Molecular and Cellular Physiology Infectious Diseases > Genetics/Genomics/Epigenetics Immune System Diseases > Genetics/Genomics/Epigenetics

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Section: Innate-like T Lymphoid Cells/unconventional T Cellsmentioning

confidence: 99%

Advances in understanding immune homeostasis in latent tuberculosis infection

Niu,

Wang,

Luo

et al. 2024

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

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Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice

du Halgouet,

Bruder,

Peltokangas

et al. 2024

Nat Immunol

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Abstractγδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a homogeneous population of cells exerting context-dependent functions. Here, by cross-organ multimodal single-cell profiling, we reveal that various mouse tissues harbor unique site-adapted γδ subsets. Epidermal and intestinal intraepithelial γδ T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity. Through parabiosis experiments, we uncovered cellular states associated with cytotoxicity, innate-like rapid interferon-γ production and tissue repair functions displaying tissue residency hallmarks. Notably, our observations add nuance to the link between interleukin-17-producing γδ T cells and tissue residency. Moreover, transcriptional programs associated with tissue-resident γδ T cells are analogous to those of CD8+ tissue-resident memory T cells. Altogether, this study provides a multimodal landscape of tissue-adapted γδ T cells, revealing heterogeneity, lineage relationships and their tissue residency program.

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Metabolic regulation of γδ intraepithelial lymphocytes

Alonso

Edelblum

2023

Discovery Immunology

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Elucidating the relationship between cellular metabolism and T cell function has substantially advanced our understanding of how T cells are regulated in response to activation. The metabolic profiles of circulating or peripheral T cells have been well-described, yet less is known regarding how complex local microenvironments shape or modulate the bioenergetic profile of tissue-resident T lymphocytes. Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide immunosurveillance of the intestinal epithelium to limit tissue injury and microbial invasion; however, their activation and effector responses occur independently of antigen recognition. In this review, we will summarize the current knowledge regarding γδ T cell and IEL metabolic profiles and how this informs our understanding of γδ IEL metabolism. We will also discuss the role of the gut microbiota in shaping the metabolic profile of these sentinel lymphocytes, and in turn, how these bioenergetics contribute to regulation of γδ IEL surveillance behavior and effector function. Improved understanding of the metabolic processes involved in γδ IEL homeostasis and function may yield novel strategies to amplify the protective functions of these cells in the context of intestinal health and disease.

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The multisensory regulation of unconventional T cell homeostasis

Cited by 5 publications

References 191 publications

Advances in understanding immune homeostasis in latent tuberculosis infection

Advances in understanding immune homeostasis in latent tuberculosis infection

Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice

Metabolic regulation of γδ intraepithelial lymphocytes

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