The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction

Bota, Daliana Peres; Mélot, Christian; Ferreira, Flávio Lopes; Ba, Vinh Nguyen; Vincent, Jean‐Louis

doi:10.1007/s00134-002-1491-3

Cited by 225 publications

(96 citation statements)

References 38 publications

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“…In a multivariable logistic regression model, the cardiovascular component was associated with the highest contribution to outcome (OR 1.68). Peres Bota and colleagues [6] reported similar findings in their assessment of the ability of the maximum SOFA and MOD scores to discriminate outcome in a mixed medical-surgical ICU. The area under the ROC curve was 0.821 for the cardiovascular component of the SOFA scoring system, as compared with 0.750 for the same component of the MOD scoring system.…”

Section: Discussionmentioning

confidence: 65%

“…The SOFA cardiovascular component is calculated based on mean arterial pressure and inotrope requirement. Despite a recent study in general systems ICU patients suggesting a stronger relationship of the SOFA cardiovascular component with mortality compared with the MOD cardiovascular component score [6], the therapy dependence of this SOFA component may not allow it to discriminate between cerebrovascular support and cardiovascular failure in patients with severe neurologic injury.…”

Section: Introductionmentioning

confidence: 99%

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“…Thrombocytopenia has been an early prognostic marker used in critically ill patients 6. For example, thrombocytopenic events were important indicators of worsened outcomes when determining Sequential Organ Failure Assessment score38 and Multiple Organ Dysfunction Score 39. Taken together, these results supported thrombocytopenia at hospital admission as being a prognostic marker of VRS outcomes in these patients with RHD.…”

Section: Discussionmentioning

confidence: 75%

Thrombocytopenia as a Preoperative Risk Assessment Tool in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Surgery

Wei

Jiang

Liu

et al. 2017

JAHA

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BackgroundPostoperative thrombocytopenia has been reported to be correlated with adverse events, but the prognostic value of baseline thrombocytopenia is unclear. This study was undertaken to evaluate the relationship between preoperative thrombocytopenia and adverse outcomes in patients with rheumatic heart disease who underwent valve replacement surgery.Methods and ResultsA total of 1789 patients with rheumatic heart disease undergoing valve replacement surgery were consecutively enrolled and postoperatively followed up for 1 year. Patients were stratified on the basis of presence (n=495) or absence (n=1294) of thrombocytopenia (platelet count, <150×109/L), according to hospital admission platelet counts. During the hospitalization period, 69 patients (3.9%) died. The in‐hospital all‐cause mortality rate was significantly higher in the thrombocytopenic group (6.9% versus 2.7%; P<0.001). Multivariate analyses revealed that thrombocytopenia was independently associated with in‐hospital all‐cause mortality (odds ratio, 2.21; 95% confidence interval, 1.29–3.80; P=0.004). Platelet counts could predict in‐hospital all‐cause mortality for patients both with and without previous atrial fibrillation (areas under the curve, 0.708 [P<0.001] and 0.610 [P=0.025], respectively). One‐year survival was significantly lower in patients with thrombocytopenia compared with controls (91.3% versus 96.1%; log‐rank=14.65; P<0.001). In addition, thrombocytopenia was an independent predictor for postoperative 1‐year all‐cause mortality in multivariate Cox regression analysis.ConclusionsPlatelet counts, as simple and inexpensive indexes, were reliable to be used as a preoperative risk assessment tool for patients with rheumatic heart disease undergoing valve replacement surgery.

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“…It was also shown to correlate with mortality from cancer, sepsis, and even stem cell transplantation [11,35]. A key factor for its success is the incorporation of therapeutical information: in cardiovascular (CV) failure, for instance, the administration of catecholamines is accounted for, which may be the main reason for its superior predictive value compared to the score by Peres Bota et al [36]. In our study, admission SOFA scores showed significant differences between both survivors and non-survivors and between septic and non-septic patients (Fig.…”

Section: Discussionmentioning

confidence: 99%

Serial lactate and admission SOFA scores in trauma: an analysis of predictive value in 724 patients with and without traumatic brain injury

Dübendorfer

Billeter

Seifert

et al. 2012

Eur J Trauma Emerg Surg

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Objective Arterial lactate, base excess (BE), lactate clearance, and Sequential Organ Failure Assessment (SOFA) score have been shown to correlate with outcome in severely injured patients. The goal of the present study was to separately assess their predictive value in patients suffering from traumatic brain injury (TBI) as opposed to patients suffering from injuries not related to the brain. Materials and methods A total of 724 adult trauma patients with an Injury Severity Score (ISS) C 16 were grouped into patients without TBI (non-TBI), patients with isolated TBI (isolated TBI), and patients with a combination of TBI and non-TBI injuries (combined injuries). The predictive value of the above parameters was then analyzed using both uni-and multivariate analyses. Results The mean age of the patients was 39 years (77 % males), with a mean ISS of 32 (range 16-75). Mortality ranged from 14 % (non-TBI) to 24 % (combined injuries). Admission and serial lactate/BE values were higher in nonsurvivors of all groups (all p \ 0.01), but not in patients with isolated TBI. Admission SOFA scores were highest in nonsurvivors of all groups (p = 0.023); subsequently septic patients also showed elevated SOFA scores (p \ 0.01), except those with isolated TBI. In this group, SOFA score was the only parameter which showed significant differences between survivors and non-survivors. Receiver operating characteristic (ROC) analysis revealed lactate to be the best overall predictor for increased mortality and further septic complications, irrespective of the leading injury. Conclusion Lactate showed the best performance in predicting sepsis or death in all trauma patients except those with isolated TBI, and the differences were greatest in patients with substantial bleeding. Following isolated TBI, SOFA score was the only parameter which could differentiate survivors from non-survivors on admission, although the SOFA score, too, was not an independent predictor of death following multivariate analysis.

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The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction

Abstract: MODS and SOFA are reliable outcome predictors. Cardiovascular dysfunction is better related to outcome with the SOFA score than with the MODS.

Cited by 225 publications

References 38 publications

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Thrombocytopenia as a Preoperative Risk Assessment Tool in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Surgery

Serial lactate and admission SOFA scores in trauma: an analysis of predictive value in 724 patients with and without traumatic brain injury

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