The multiple facets of premature aging in rheumatoid arthritis

Straub, Rainer H.; Schölmerich, Jürgen; Cutolo, Maurizio

doi:10.1002/art.11290

Cited by 30 publications

(22 citation statements)

References 63 publications

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“…Many of the comorbidities, including low skeletal muscle mass and function [2] and osteoporosis [3], would be expected to occur in a comparatively older population as part of physiological ageing, yet are evident in patients with CF in their second and third decade of life. Similar comorbidities are a feature of other disorders with a chronic systemic inflammatory component, such as rheumatoid arthritis and chronic obstructive pulmonary disease (COPD), where there is again apparent dissociation of physiological and chronological ageing [4][5][6].…”

mentioning

confidence: 88%

Increased augmentation index in patients with cystic fibrosis

Hull

Garrod²,

Ho³

et al. 2009

European Respiratory Journal

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Increased large artery stiffness occurs in a range of inflammatory conditions indicating an ageing of the vasculature and additionally being an independent risk factor for cardiovascular events. We determined large artery parameters in adults with cystic fibrosis (CF).50 clinically stable adult patients with CF (mean¡SD age 28.0¡8.2 yrs) and 26 controls matched for age, sex and body mass index were studied. Central aortic blood pressure, augmentation index (AIx) and aortic pulse wave velocity (PWV) were determined using applanation tonometry. Lung function, diabetic status and C-reactive protein (CRP) were also determined.Mean¡SD AIx was greater in patients than controls, 8.5¡11.1% and -1.8¡13.1%, respectively (p,0.001), while PWV was similar. Although AIx was greatest in the sub-group with CF-related diabetes (CFRD), it was also increased in the non-CFRD sub-group when compared with controls. In patients, AIx was related to log 10 CRP (r50.33) and forced vital capacity (r5 -0.34; both p,0.05), and CRP remained predictive in multiple regression.AIx is increased in adults with CF, in the presence of a normal blood pressure and independent of diabetic status. AIx was related to the systemic inflammatory status. These findings have implications for management and require further exploration so that cardiovascular health can be maintained.

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mentioning

confidence: 88%

Increased augmentation index in patients with cystic fibrosis

Hull

Garrod²,

Ho³

et al. 2009

European Respiratory Journal

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“…This scenario leads to a myriad of inflammatory disorders associated with aging. As stated above, age-associated RA is characterized by a sequence of age-dependent degenerative conditions which starts with an acute inflammatory reaction that is perpetuated into endocrinosenescence, neurosenescence, and senescence of the muscular system [22]. Beside of this, age exponentially increases CVD risk in RA patients [21].…”

Section: Suppression Of the Heat Shock Response In Agerelated Degenermentioning

confidence: 99%

“…This is noteworthy because people with RA die at a younger age than people without the disease, whereas age exerts an exponentially increasing effect on CVD risk in RA patients [21]. RA is characterized by a sequence of age-dependent degenerative conditions that usually starts with an acute inflammatory reaction, followed by a continuous pro-inflammatory overburden that induces endocrinosenescence, neurosenescence, and senescence of the muscular system [7,22]. Age-related premature atherosclerosis has also been recognized as an important factor in the morbidity and mortality of patients with systemic lupus erythematosus (SLE), this being attributed to vasculitis and corticosteroid use by these patients [22].…”

Section: Age-related Inflammatory Diseases Of High Prevalencementioning

confidence: 99%

“…RA is characterized by a sequence of age-dependent degenerative conditions that usually starts with an acute inflammatory reaction, followed by a continuous pro-inflammatory overburden that induces endocrinosenescence, neurosenescence, and senescence of the muscular system [7,22]. Age-related premature atherosclerosis has also been recognized as an important factor in the morbidity and mortality of patients with systemic lupus erythematosus (SLE), this being attributed to vasculitis and corticosteroid use by these patients [22]. SLE is an autoimmune multi-system disease frequently accompanied by arthritis, fever, serositis, Raynaud's syndrome, lung disease, and neuropsychiatric symptoms that are very common among elderly patients [23].…”

Section: Age-related Inflammatory Diseases Of High Prevalencementioning

confidence: 99%

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Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions

Leite

Cruzat

Krause

et al. 2016

Nutrire

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Aging is an intricate process modulated by different molecular and cellular events, such as genome instability, epigenetic and transcriptional changes, molecular damage, cell death and senescence, inflammation, and metabolic dysfunction. Particularly, protein quality control (chaperone systems) tends to be negatively affected by aging, thus leading to cellular senescence in metabolic tissues and, as a consequence, to the increasing dissemination of inflammation throughout the body. The heat shock (HS) response and its associated expression of the 70 kDa family of heat shock proteins (HSP70), which are anti-inflammatory molecular chaperones, are found to be markedly decreased during muscle inactivity and aging, while evidence supports the loss of HSP70 as a key mechanism which may drive muscle atrophy, contractile dysfunction, and reduced regenerative capacity. In addition, abnormal stress response is linked with higher incidence of neurodegenerative diseases as well as low-grade inflammatory diseases that are associated with physical inactivity and obesity. Therefore, strategies to increase or, at least, to maintain the levels of HSP70, and its accompanying HS response to stress, are key to reduce biological cell dysfunctions that occur in aging. In this sense, physical exercise is of note as it is the most powerful inducer of the HS response, comparable only to heat stress and fever-like conditions. On the other hand, the amino acid L-glutamine, whose production within the skeletal muscle and liberation into the blood stream is dependent on muscle activity, is a potentializer of HSP70 expression and HS response, particularly via its entering in hexosamine biosynthetic pathway (HBP). Herein, we discuss the collaborative role of glutamine (and its donors/precursors) and physical exercise (mostly responsible for glutamine release into the circulation) as potential tools to increase HSP70 expression and the HS response in the elderly.

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“…It is noteworthy to mention that elderly subjects are particularly at risk for both infectious and chronic inflammatory diseases. Furthermore, chronic inflammatory diseases may be associated with premature aging of the immune system and present several similarities of immunosenescence including shortening of cellular telomeres, decreased T-cell receptor specificities, loss of naïve T-cells and increased production of proinflammatory cytokines (Straub et al 2003 ). Dysregulation of the HPA axis may contribute to but it is not solely responsible to immunosenescence.…”

Section: Introductionmentioning

confidence: 99%