The multiple facets of periostin in bone metabolism

Merle, Blandine; Garnero, Patrick

doi:10.1007/s00198-011-1892-7

Cited by 169 publications

(149 citation statements)

References 101 publications

(245 reference statements)

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“…Recently, increasing evidence also suggests that periostin is involved in the development of multiple tumors via several signaling pathways, such as PI3K/AKT and Wnt/β-catenin (8)(9)(10)(11). In agreement with this, periostin expression is markedly upregulated in various human tumors, including in head and neck, breast, colon, pancreatic, and ovarian cancers (7,12). However, the role of periostin in the regulation of TG homeostasis and in the pathogenesis of NAFLD remains uncharacterized.…”

Section: Introductionmentioning

confidence: 80%

“…To investigate the long-term effect of periostin deficiency on hepatosteatosis, we used Postn-heterozygous mice, since Postn homozygotes exhibit postnatal growth retardation and skeletal defects (6,7). Postn-heterozygous mice showed a 58% reduction in Postn mRNA and a 41% reduction in periostin protein in the liver (Supplemental Figure 12, A and B).…”

Section: Disruption Of Postn Improves Hepatosteatosis In Obese Micementioning

confidence: 99%

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Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

Lu¹,

Liu²,

Jiao³

et al. 2014

J. Clin. Invest.

114

128

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Periostin neutralizing Ab. The hybridoma cell lines secreting mouse mAb against mouse periostin were generated by Abmart Co., according to the standard hybridoma technique (72). The mouse mAbs were purified by Protein A affinity chromatograph. mAb purity was confirmed by HPLC. The concentrations of the obtained mAbs were measured by Mouse IgG ELISA Quantitation kit (Bethyl Laboratories), following the manufacturer's instructions. The kinetic parameters of the mAbs were determined using a Biacore T100 instrument (Biacore AB). Purified Ab was diluted in saline and injected at a dose of 5 mg/kg into db/db mice for 2 weeks.Statistics. All values are shown as mean ± SEM. Statistical differences were determined by 2-way ANOVA with Bonferroni-adjusted post-test or by 2-tailed Student's t test. A P value less than 0.05 was considered significant.

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Section: Introductionmentioning

confidence: 80%

Section: Disruption Of Postn Improves Hepatosteatosis In Obese Micementioning

confidence: 99%

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

Lu¹,

Liu²,

Jiao³

et al. 2014

J. Clin. Invest.

114

128

View full text Add to dashboard Cite

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“…LOX is responsible for the synthesis of pyridinium cross-links, further linking collagen fibers. 70 Collagen and bone strength P Garnero Indeed some studies report that AGEs may enhance osteoclastinduced bone resorption in a model where in vitro ribosylated bone particles are subcutaneously implanted in rats. 18 In contrast, in another study in which human osteoclasts were seeded on bone slices, treated with a high dose of exogenous ribose, the activity of human osteoclasts was decreased.…”

Section: Figurementioning

confidence: 99%

The contribution of collagen crosslinks to bone strength

Garnero¹

2012

BoneKEy Reports

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Collagen crosslinking is a major post-translational modification of collagen which has important roles in determining the biomechanical competence of bone. Crosslinks can be divided into enzymatic lysil oxidase-mediated and nonenzymatic glycation-induced (advanced glycation end products, AGE) molecules. In addition, collagen in bone can also undergo spontaneous isomerization and racemization of the aspartic acid residues with the C-telopeptide (CTX), leading to the formation of two isomers namely ␣ (newly formed collagen) and ␤ (matured isomerized collagen) CTX. Several in vitro and ex vivo studies, relating the bone content of these crosslinks with bone strength, have shown that they contributed to the mechanical competence of trabecular and cortical bone -mainly on the post-yield properties -in part independent of the bone mineral content. In addition, AGEs such as pentosidine have been reported to alter the formation and propagation of microdamage by making the bone more brittle. The bone content of AGEs and isomerization can also be modified by antiresorptive and anabolic therapies. They may thus explain part of the antifracture efficacy of these treatments. The main challenge consists in the transposition of these in vitro / ex vivo studies to clinical applications for the development of a non-invasive biomarker, as none of currently identified collagen crosslinks (both enzymatic and nonenzymatic) is bone specific. Nevertheless, serum or urine levels of pentosidine and the ratio of ␣ / ␤ CTX have been reported to predict fracture risk in postmenopausal women, in men and in patients with type 2 diabetes.

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“…The periosteum is a complex structure composed of an outer fibrous layer predominantly consisting of collagen that lends structural integrity, and a highly cellular inner layer of mesenchymal progenitor cells that possess the potential to differentiate into osteoblasts or fibroblasts (6). The periosteum is particularly active during the period of skeletal growth, contributing to the determination of bone diameter and muscular strength, and in fracture consolidation, playing a fundamental role in the processes of bone regeneration (7). The osteoblastic potential of the periosteum varies with age and with localization.…”

Section: Discussionmentioning

confidence: 99%

Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina

Mastaglia

Mautalén²

2015

ccmbm

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SummaryOssifying fibroma (OF) of the long bones is a benign fibro-osseous lesion typically seen in the first decade of life. OF usually progresses until the age of 10 years, but is occasionally found to regress spontaneously after puberty. The pathogenesis of OF is unknown; however, it has been suggested that the basic defect is in the periosteum. We present the radiological course of an OF of the tibia in a young patient, showing a rapid almost complete regression of the lesion after a tibial fracture at the lesion site. We postulate that the fracture-induced activation of the periosteum in a growing skeleton was fundamental to the regression of the lesion. KEY WORDS: ossifying fibroma; periosteum, regression lesion.

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The multiple facets of periostin in bone metabolism

Cited by 169 publications

References 101 publications

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα

The contribution of collagen crosslinks to bone strength

Regression of an ossifying fibroma of the tibia after a fracture involving the lesion. Possible role of the periostina

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