The Multimodality Management of Malignant Peripheral Nerve Sheath Tumours
Remus Seres,
Hassan Hameed,
Martin G. McCabe
et al.
Abstract:Malignant peripheral nerve sheath tumours (MPNST) are aggressive sarcomas that have nerve sheath differentiation and can present at any anatomical site. They can arise from precursor neurofibroma in the context of neurofibromatosis type 1 (NF1) or as de novo and sporadic tumours in the absence of an underlying genetic predisposition. The primary therapeutic approach is most often radical surgery, with non-surgical modalities playing an important role, especially in locally advanced or metastatic cases. The aim… Show more
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