The Multifunctional Roles of Short Palate, Lung, and Nasal Epithelium Clone 1 in Regulating Airway Surface Liquid and Participating in Airway Host Defense

Integrated bioinformatics analysis and experimental animal models identify a robust biomarker and its correlation with the immune microenvironment in pulmonary arterial hypertension

“…Genomic and proteomic studies have indicated differential expression of Bpifa1 in lung diseases, and multifaceted BPIFA1 has been established to possess both pro-inflammatory and anti-inflammatory effects [ 59 ]. In an allergic airway inflammation model, mice lacking BPIFA1 displayed increased airway inflammation accompanied by increased eosinophil counts, augmented mucus production, airway hyperreactivity, and elevated T levels [ 60 ]. Previous research postulated that BPIFA1 does not only influence chemokine expression but also exerts a moderate chemotactic effect on macrophages and neutrophils [ 61 ].…”