2016
DOI: 10.1016/j.bbamcr.2016.03.026
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The multifaceted roles of the invariant chain CD74 — More than just a chaperone

Abstract: The invariant chain (CD74) is well known for its essential role in antigen presentation by mediating assembly and subcellular trafficking of the MHCII complex. Beyond this, CD74 has also been implicated in a number of processes independent of MHCII. These include the regulation of endosomal trafficking, cell migration and cellular signalling as surface receptor of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). In several forms of cancer, CD74 is up-regulated and associated with enh… Show more

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Cited by 195 publications
(217 citation statements)
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“…Rather, this Ii domain initiates a signaling cascade, resulting in NFkB activation and B cell maintenance (152). The intramembrane protease SPPL2a (presenilin homolog signal-peptide-peptidase-like 2a) catalyzes the generation of this Ii fragment in mice and human B cells (153) Ii has third role for B cells as the receptor for macrophage migration inhibitory factor and interaction leads to signaling cascade that promotes B cell chemotaxis and survival (154). …”
Section: Mhcii Antigen Presentation Over the Span Of B Cell Developmentmentioning
confidence: 99%
“…Rather, this Ii domain initiates a signaling cascade, resulting in NFkB activation and B cell maintenance (152). The intramembrane protease SPPL2a (presenilin homolog signal-peptide-peptidase-like 2a) catalyzes the generation of this Ii fragment in mice and human B cells (153) Ii has third role for B cells as the receptor for macrophage migration inhibitory factor and interaction leads to signaling cascade that promotes B cell chemotaxis and survival (154). …”
Section: Mhcii Antigen Presentation Over the Span Of B Cell Developmentmentioning
confidence: 99%
“…It is cleared from the membrane by regulated intramembrane proteolysis (RIP), which causes the two resulting fragments to be released to either side of the membrane. This process resembles the way in which the intra-membrane proteases presenillin and signal peptidase act on their substrates [30]. The protease in charge of cleaving NTF within the membrane has recently been identified as a member of the signal peptidase family and has been termed signal peptide peptidase-like 2a (SPPL-2a) [98,99,100,101].…”
Section: Mif-induced Signaling From Invariant Chain Complexesmentioning
confidence: 99%
“…Here, I will provide a short overview of both lives of Ii and then briefly discuss new results that show promise to integrate the two fields. Invariant chain has been the topic of an excellent recent review by Schröder [30] and the readers are referred to this paper for a concise coverage of Ii biology.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, load-independent changes were also evidenced on the non-CCL treated contralateral limb, indicating a systemic response of the massage-mimetic treatment [46]. From the 47% of the functional gene ontology clusters associating with immune response after CCL, the authors validated the chemokine (C-C motif) receptor CCR2, a critical regulator of skeletal muscle regeneration [47,48]; the leukocyte immunoglobulin like receptor B4 (Lilrb4), alias ILT3, thought to control inflammatory responses and limit autoreactivity through Treg enhancement [49]; the major histocompatibility complex (class II) molecule Cd74, an important regulator of immunity and inflammation with an impact on the cell endosomal compartment [50]; and the lysozyme 2 (Lyz2) gene involved in activities such as reducing the presence of proinflammatory cytokines (TNF-α, IL-6, INF-γ, IL-8 and IL-17) while increasing levels of anti-inflammatory cytokines (IL-4 and TGF-β) [51]; by the cost-effective alternative approach RT-qPCR (real time polymerase chain reaction after retrotranscription) which entitles a rather easy implementation of molecular marker monitorization in follow-up studies. All these molecular changes appeared unaffected in low load treatments (1.4 N) and upregulated by medium load treatments (4.5 N) indicating that a minimum pressure is required to register the effect.…”
Section: Neuroimmune Impact Of Mtmentioning
confidence: 99%