The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Huber, Katharina; Mestres‐Arenas, Alberto; Fajas, Lluís; Leal‐Esteban, Lucia C.

doi:10.1111/febs.15586

Cited by 36 publications

(26 citation statements)

References 168 publications

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“…Cell cycle progression is the base of cell proliferation, tightly mediated by cell cycle-related proteins, such as cyclins and cyclin-dependent kinases (CDKs), and depends on the G1 checkpoint [ 26 ]. Cyclin D1 is a key regulator and leads to promotion of the G1 to S phase.…”

Section: Discussionmentioning

confidence: 99%

Novel Ferrocene Derivatives Induce G0/G1 Cell Cycle Arrest and Apoptosis through the Mitochondrial Pathway in Human Hepatocellular Carcinoma

Zheng

Zeng

Tang

et al. 2021

IJMS

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In this study, detailed information on hepatocellular carcinoma (HCC) cells (HepG-2, SMMC-7721, and HuH-7) and normal human liver cell L02 treated by ferrocene derivatives (compounds 1, 2 and 3) is provided. The cell viability assay showed that compound 1 presented the most potent and selective anti-HCC activity. Further mechanism study indicated that the proliferation inhibition effect of compound 1 was associated with the cycle arrest at the G0/G1 phase and downregulation of cyclin D1/CDK4. Moreover, compound 1 could induce apoptosis in HCC cells by loss of mitochondrial membrane potential (ΔΨm), accumulation of reactive oxygen species (ROS), decrease in Bcl-2, increase in BAX and Bad, translocation of Cytochrome c, activation of Caspase-9, -3, and cleavage of PARP. These results indicated that compound 1 would be a promising candidate against HCC through G0/G1 cell cycle arrest-related proliferation inhibition and mitochondrial pathway-dependent apoptosis.

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Section: Discussionmentioning

confidence: 99%

Novel Ferrocene Derivatives Induce G0/G1 Cell Cycle Arrest and Apoptosis through the Mitochondrial Pathway in Human Hepatocellular Carcinoma

Zheng

Zeng

Tang

et al. 2021

IJMS

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“…Plant growth depends on the correct coordination of cell division [ 58 ]. CDKs are at the center of these controls, acting in response to environmental signals and inner developmental stages [ 14 ].…”

Section: Regulators Of Cdk Activitymentioning

confidence: 99%

Plant CDKs—Driving the Cell Cycle through Climate Change

Carneiro

Montessoro

Fusaro

et al. 2021

Plants

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In a growing population, producing enough food has become a challenge in the face of the dramatic increase in climate change. Plants, during their evolution as sessile organisms, developed countless mechanisms to better adapt to the environment and its fluctuations. One important way is through the plasticity of their body and their forms, which are modulated during plant growth by accurate control of cell divisions. A family of serine/threonine kinases called cyclin-dependent kinases (CDK) is a key regulator of cell divisions by controlling cell cycle progression. In this review, we compile information on the primary response of plants in the regulation of the cell cycle in response to environmental stresses and show how the cell cycle proteins (mainly the cyclin-dependent kinases) involved in this regulation can act as components of environmental response signaling cascades, triggering adaptive responses to drive the cycle through climate fluctuations. Understanding the roles of CDKs and their regulators in the face of adversity may be crucial to meeting the challenge of increasing agricultural productivity in a new climate.

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“…Their binding to pocket proteins RB, p107 also known as RBL1 and p130 also known as RBL2) are regulated by cyclin/CDK complexes, which phosphorylate pocket proteins, thereby causing the release of E2Fs from pocket proteins and the induction of E2F-dependent transcriptional activation. E2F targets include genes involved in the regulation of a myriad of cellular processes, such as the mitotic checkpoint, DNA-damage checkpoints, DNA synthesis and repair, differentiation, development, apoptosis, and metabolism [ 72 , 73 , 74 , 75 , 76 ]. E2F1 is also a transcriptional regulator of autophagy.…”

Section: Cell-cycle Regulators Modulate Autophagymentioning

confidence: 99%

The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer

Ziegler

Huber

Fajas

2021

Cancers

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In the past decade, cell cycle regulators have extended their canonical role in cell cycle progression to the regulation of various cellular processes, including cellular metabolism. The regulation of metabolism is intimately connected with the function of autophagy, a catabolic process that promotes the efficient recycling of endogenous components from both extrinsic stress, e.g., nutrient deprivation, and intrinsic sub-lethal damage. Mediating cellular homeostasis and cytoprotection, autophagy is found to be dysregulated in numerous pathophysiological contexts, such as cancer. As an adaptative advantage, the upregulation of autophagy allows tumor cells to integrate stress signals, escaping multiple cell death mechanisms. Nevertheless, the precise role of autophagy during tumor development and progression remains highly context-dependent. Recently, multiple articles has suggested the importance of various cell cycle regulators in the modulation of autophagic processes. Here, we review the current clues indicating that cell-cycle regulators, including cyclin-dependent kinase inhibitors (CKIs), cyclin-dependent kinases (CDKs), and E2F transcription factors, are intrinsically linked to the regulation of autophagy. As an increasing number of studies highlight the importance of autophagy in cancer progression, we finally evoke new perspectives in therapeutic avenues that may include both cell cycle inhibitors and autophagy modulators to synergize antitumor efficacy.

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The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

Cited by 36 publications

References 168 publications

Novel Ferrocene Derivatives Induce G0/G1 Cell Cycle Arrest and Apoptosis through the Mitochondrial Pathway in Human Hepatocellular Carcinoma

Novel Ferrocene Derivatives Induce G0/G1 Cell Cycle Arrest and Apoptosis through the Mitochondrial Pathway in Human Hepatocellular Carcinoma

Plant CDKs—Driving the Cell Cycle through Climate Change

The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer

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