The multifaceted role of CD146/MCAM in the promotion of melanoma progression

Lei, Xing; Guan, Ce-Wen; Song, Yang; Wang, Huan

doi:10.1186/s12935-014-0147-z

Cited by 52 publications

(54 citation statements)

References 79 publications

(144 reference statements)

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“…However, Shadow, cRGO1 and cRGO3 did not exhibit this feature. Based on previous reports on the multifaceted role of CD146 as promoter of human melanoma progression, our findings may reflect the advanced/metastatic state of cRGO1.1, cRGO1.2 and cRGO2. However, CD146‐overexpressing cRGO1 revealed CD146‐independent migratory and invasive behaviour, indicating that CD146 expression alone might not suffice to drive tumour cell dissemination .…”

Section: Discussionsupporting

confidence: 62%

“…Based on previous reports on the multifaceted role of CD146 as promoter of human melanoma progression, our findings may reflect the advanced/metastatic state of cRGO1.1, cRGO1.2 and cRGO2. However, CD146‐overexpressing cRGO1 revealed CD146‐independent migratory and invasive behaviour, indicating that CD146 expression alone might not suffice to drive tumour cell dissemination . Together with constant cell doubling times as observed over 48 passages by May 2018, consistent expression of canine CD146 in tumours and by all primary cell lines confirmed their identity and suggested CD146 as additional marker for COMM, irrespective of the degree of pigmentation.…”

Section: Discussionmentioning

confidence: 53%

“…Furthermore this protein drives metastasis by (a) inducing heterotypic adhesion and diapedesis, (b) contributing to the degradation of the ECM, (c) supporting MM cell motility and (d) promoting tumour vascularization. Hence, CD146 has been proposed as additional driver of EMT and valuable prognostic marker …”

Section: Introductionmentioning

confidence: 93%

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Canine oral primary melanoma cells exhibit shift to mesenchymal phenotype and phagocytic behaviour

Schmid

Brodesser

Reifinger

et al. 2019

Vet Comparative Oncology

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Canine oral malignant melanoma (COMM) is a potentially lethal cancer disease. We established primary cell lines from mostly amelanotic primary COMM and metastases and assessed lesions and derived cells for Melan A, PNL2 and CD146 expression. Then, migration and invasion of CD146‐enriched vs ‐depleted COMM cells were analysed. Epithelial‐to‐mesenchymal transition (EMT) was addressed by Vimentin‐staining and MMP2/MMP9 zymography. Phagocytic behaviour was analysed by histopathological examination and phagocytosis assay. While Melan A‐ and PNL2‐staining yielded inconsistent data, 100% of COMM sections and primary cells showed CD146 expression, suggesting that this protein may serve as a prognostic marker. An overall correlation between CD146‐expression and migration/invasion was not observed. All primary cell lines consistently expressed Vimentin and secreted biologically active MMP2, indicating that they had undergone EMT. Importantly, COMM sections exhibited cell‐in‐cell structures, and all primary cell lines exhibited phagocytic activity, supporting the concept that cell cannibalism may have a role in COMM progression.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 53%

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Canine oral primary melanoma cells exhibit shift to mesenchymal phenotype and phagocytic behaviour

Schmid

Brodesser

Reifinger

et al. 2019

Vet Comparative Oncology

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“…In addition, previous studies have linked CD146 with apoptosis resistance in cancer cells (21,22). To additionally verify whether expression of CD146 is induced by vorinostat, the present study investigated the effects of vorinostat on mRNA and protein expression of CD146 in ovarian cancer cells.…”

Section: Resultsmentioning

confidence: 99%

Targeting CD146 in combination with vorinostat for the treatment of ovarian cancer cells

Wang

Liu

et al. 2017

Oncology Letters

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Drug resistance is the predominant cause of mortality in late-stage patients with ovarian cancer. Histone deacetylase inhibitors (HDACis) have emerged as a novel type of second line drug with high specificity for tumor cells, including ovarian cancer cells. However, HDACis usually exhibit relatively low potencies when used as a single agent. The majority of current clinical trials are combination strategies. These strategies are more empirical than mechanism-based applications. Previously, it was reported that the adhesion molecule cluster of differentiation 146 (CD146) is significantly induced in HDACi-treated tumor cells. The present study additionally confirmed that the induction of CD146 is a common phenomenon in vorinostat-treated ovarian cancer cells. AA98, an anti-CD146 monoclonal antibody (mAb), was used to target CD146 function. Synergistic antitumoral effects between AA98 and vorinostat were examined in vitro and in vivo. The potential effect of combined AA98 and vorinostat treatment on the protein kinase B (Akt) pathway was determined by western blotting. The present study found that targeting of CD146 substantially enhanced vorinostat-induced killing via the suppression of activation of Akt pathways in ovarian cancer cells. AA98 in combination with vorinostat significantly inhibited cell proliferation and increased apoptosis. In vivo, AA98 synergized with vorinostat to inhibit tumor growth and prolong survival in ovarian cancer. These data suggest that an undesired induction of CD146 may serve as a protective response to offset the antitumor efficacy of vorinostat. By contrast, targeting CD146 in combination with vorinostat may be exploited as a novel strategy to more effectively kill ovarian cancer cells.

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“…It is possible that men with higher sperm counts have higher levels of melanoma cell adhesion molecule (MCAM), which has been shown to be critical for spermatogonial stem cell proliferation in animal models (19) and has been demonstrated to drive melanoma progression (20). These findings will need to be validated in other cohorts.…”

Section: Discussionmentioning

confidence: 99%

Subfertility increases risk of testicular cancer: evidence from population-based semen samples

Hanson

Anderson

Aston

et al. 2016

Fertility and Sterility

100

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Objective To further understand the association between semen quality and cancer risk using well-defined semen parameters. Design Retrospective cohort study. Setting Subfertility Heath and Assisted Reproduction (SHARE) study in Utah from 1994 to 2011. Patients 20,433 men from that underwent semen analysis (SA) and a sample of 20,433 fertile controls matched on age and birth year Interventions none. Main Outcome Measures Risk of all cancers, as well as site-specific results for prostate, testicular, and melanoma. Results Relative to fertile men, men with SA have an increased risk of testicular cancer (Hazard Rate Ratio (HR) =3.3). When the characterization of infertility is refined using individual semen parameters, we find that oligozoospermic men have an increased risk of cancer relative to fertile controls. This association is particularly strong for testicular cancer, with increased risk in men with oligozoospermia based on concentration (HR=11.9) and sperm count (HR=10.3). Men in the in the lowest quartile of motility (HR=4.1), viability (HR=6.6), morphology (HR=4.2) or total motile count (HR=6.9) have higher risk of testicular compared to fertile men. Men with sperm concentration and count in the 90th percentile of the distribution (≥178 M/ml and ≥579, respectively) and total motile count (TMC) have an increased risk of melanoma (HRConcentration=2.1; HRCount=2.7; HRTMC=2.0). We find no differences in cancer risk between azoospermic and fertile men. Conclusions Men with SA have an increased risk of testicular cancer that varies by semen quality. Unlike prior work, we did not find an association between azoospermia and increased cancer or testicular cancer risk. Capsule Subfertile men have an increased risk of testicular cancer that varies by semen quality. We did not find an association between azoospermia and increased cancer or testicular cancer risk.

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The multifaceted role of CD146/MCAM in the promotion of melanoma progression

Cited by 52 publications

References 79 publications

Canine oral primary melanoma cells exhibit shift to mesenchymal phenotype and phagocytic behaviour

Canine oral primary melanoma cells exhibit shift to mesenchymal phenotype and phagocytic behaviour

Targeting CD146 in combination with vorinostat for the treatment of ovarian cancer cells

Subfertility increases risk of testicular cancer: evidence from population-based semen samples

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