The Multifaceted Role of Annexin A1 in Viral Infections

Abstract

Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the termination of response, clearance of pathogen and restoration of tissue homeostasis. Harnessing the pro-resolution actions of AnxA1 holds promise as a therapeutic strategy to control the severity of the clinical presentation of viral infections. In contrast, AnxA1 signaling might also be hijacked by viruses to promote pathogen survival and replication. Therefore, the role of AnxA1 during viral infections is complex and dynamic. In this review, we provide an in-depth view of the role of AnxA1 during viral infections, from pre-clinical to clinical studies. In addition, this review discusses the therapeutic potential for AnxA1 and AnxA1 mimetics in treating viral infections.

Analyzing secretory proteins in human dermal fibroblast‐conditioned medium for angiogenesis: A bioinformatic approach

“… 27 It is also involved in the apoptosis of inflammatory cells, efferocytosis and phagocytosis of apoptotic cells, pathogens, and debris, as well as the resolution of the inflammatory tissue environment. 28 Previous research has demonstrated that annexin A1 treatment promotes the angiogenesis process and mitigates exacerbated inflammation, ultimately improving tissue regeneration following skin grafting. 29 …”