The multifaceted presentation of tuberculosis in gynaecology: A masquerader as cervical cancer as well as a cause of primary infertility in the same patient

W, Kumakech; Zamblera, Dan; Jolaoso, A.

doi:10.1080/01443610500475693

Cited by 6 publications

(4 citation statements)

References 3 publications

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“…Disseminated (gynecologic) TB has the potential to lead to delays in cervical cancer diagnosis and an increase in morbidity and mortality during cancer treatment. 11 Conversely, cervical cancer diagnosis may delay the diagnosis and treatment initiation of coexisting TB. 11,12 Although TB has not been associated with the development of cervical cancer, chronic TB infection and inflammation in the gynecologic tract is an important cause of infertility in the developing world.…”

Section: Discussionmentioning

confidence: 99%

“…11 Conversely, cervical cancer diagnosis may delay the diagnosis and treatment initiation of coexisting TB. 11,12 Although TB has not been associated with the development of cervical cancer, chronic TB infection and inflammation in the gynecologic tract is an important cause of infertility in the developing world. 13 Thus, the chronic inflammation due to chronic gynecologic TB infection might be a contributing factor in the progression toward cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

“…13 Thus, the chronic inflammation due to chronic gynecologic TB infection might be a contributing factor in the progression toward cervical cancer. 11,13,14 HIV infection is associated with a higher incidence, as well as increased morbidity and mortality, of both TB and cervical cancer, independently. Whether HIV infection modifies the relationship between TB and cervical cancer remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

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Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana

Zetola

Grover

Modongo

et al. 2016

JGO

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Cervical cancer is the leading cause of cancer-related mortality in the developing world, where HIV and Mycobacterium tuberculosis (TB) infection are also endemic. HIV infection is independently associated with increased morbidity and mortality among women with cervical cancer. TB is believed to increase the risk of malignancies and could cause chronic inflammation in the gynecologic tract. However, the relationship between cervical cancer and TB in settings hyperendemic for HIV is unknown. We found that 18 (10%) of a cohort of 180 women with cervical cancer in Botswana had a history of TB disease. Age and HIV infection were also associated with a history of TB disease. Our data show that prior TB disease is highly prevalent among patients with cervical cancer infected with HIV. The coexistence of cervical cancer, HIV infection, and prior TB infection might be higher than expected in the general population. Prospective studies are needed to better determine the impact of the collision of these three world health epidemics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana

Zetola

Grover

Modongo

et al. 2016

JGO

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“…Although genital tract TB is characterized by a range of clinical presentations, it is an important cause of male and female infertility 36–40 . More than a decade ago, Jordaan et al 8 highlighted the preponderance of PNT in women and recommended thorough investigation of the genital tract in women with PNT.…”

Section: Discussionmentioning

confidence: 99%

Tuberculids as sentinel lesions of tuberculous epididymo‐orchitis

et al. 2007

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An update on lower urinary tract tuberculosis

Wise

Shteynshlyuger²

2007

Current prostate reports

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Tuberculosis of the genitourinary tract presents with atypical manifestations. Only 20% to 30% of patients with genitourinary tuberculosis have a history of pulmonary infection. Tuberculosis often affects the lower genitourinary system rather than the kidney. Tuberculosis of the lower genitourinary tract most commonly affects the epididymis and the testis, followed by bladder, ureter, prostate, and penis. Use of bacillus Calmette-Guérin therapy for bladder cancer can cause symptomatic tubercular infections of the lower genitourinary tract. Tuberculosis of the lower genitourinary tract can present with irritative voiding symptoms, hematuria, epididymo-orchitis, prostatitis, and fistulas. Tuberculosis of the seminal vesicles, vas, fallopian tubes, and the uterus can cause infertility. Urinalysis may demonstrate sterile pyuria, hematuria, or albuminuria. Identification of acid-fast bacilli in culture or tissue or by polymerase chain reaction studies is diagnostic. Medical treatment may not result in resolution of symptoms. Surgical intervention and reconstruction of the urinary tract are frequently indicated.

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The multifaceted presentation of tuberculosis in gynaecology: A masquerader as cervical cancer as well as a cause of primary infertility in the same patient

Cited by 6 publications

References 3 publications

Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana

Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana

Tuberculids as sentinel lesions of tuberculous epididymo‐orchitis

An update on lower urinary tract tuberculosis

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