The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma

Chidambaranathan-Reghupaty, Saranya; Mendoza, Rachel G.; Fisher, Paul B.; Sarkar, Devanand

doi:10.20517/2394-5079.2018.34

Cited by 18 publications

(13 citation statements)

References 59 publications

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“…SND1 is involved in cell signalling pathways (such as STAT, NF- κ B and Wnt pathways), miRNA splicing process, gene silencing, cell viability and cell proliferation (Ref. 27). Santhekadur et al .…”

Section: Cxcl16 Expression In Cancermentioning

confidence: 99%

CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

Shabgah

Qasim

Mostafavi³

et al. 2021

Expert Rev. Mol. Med.

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Today, cancer is one of the leading causes of death worldwide. Lately, cytokine and chemokine imbalances have gained attention amongst different involved pathways in cancer development and attracted much consideration in cancer research. CXCL16, as a member of the CXC subgroup of chemokines, has been attributed to be responsible for immune cell infiltration into the tumour microenvironment. The aberrant expression of CXCL16 has been observed in various cancers. This chemokine has been shown to play a conflicting role in tumour development through inducing pro-inflammatory conditions. The infiltration of various immune and non-immune cells such as lymphocytes, cancer-associated fibroblasts and myeloid-derived suppressor cells by CXCL16 into the tumour microenvironment has complicated the tumour fate. Given this diverse role of CXCL16 in cancer, a better understanding of its function might build-up our knowledge about tumour biology. Hence, this study aimed to review the impact of CXCL16 in cancer and explored its therapeutic application. Consideration of these findings might provide opportunities to achieve novel approaches in cancer treatment and its prognosis.

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Section: Cxcl16 Expression In Cancermentioning

confidence: 99%

CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

Shabgah

Qasim

Mostafavi³

et al. 2021

Expert Rev. Mol. Med.

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“…The potent interaction capacity of SN domains with RNA (6) and of the Tudor domain with modified (methylated) aminoacids (7, 8), together with its intrinsic endonuclease activity (9) for degrading double-stranded RNA (10) enable SND1 for participating in an unusual multiplicity of functions (summarized in Figure 1). We refer the reader to some recent reviews addressing the biochemistry and function of this protein (11–13).…”

Section: Introductionmentioning

confidence: 99%

Insights Into SND1 Oncogene Promoter Regulation

2018

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The staphylococcal nuclease and Tudor domain containing 1 gene (SND1), also known as Tudor-SN, TSN or p100, encodes an evolutionarily conserved protein with invariant domain composition. SND1 contains four repeated staphylococcal nuclease domains and a single Tudor domain, which confer it endonuclease activity and extraordinary capacity for interacting with nucleic acids, individual proteins and protein complexes. Originally described as a transcriptional coactivator, SND1 plays fundamental roles in the regulation of gene expression, including RNA splicing, interference, stability, and editing, as well as in the regulation of protein and lipid homeostasis. Recently, SND1 has gained attention as a potential disease biomarker due to its positive correlation with cancer progression and metastatic spread. Such functional diversity of SND1 marks this gene as interesting for further analysis in relation with the multiple levels of regulation of SND1 protein production. In this review, we summarize the SND1 genomic region and promoter architecture, the set of transcription factors that can bind the proximal promoter, and the evidence supporting transactivation of SND1 promoter by a number of signal transduction pathways operating in different cell types and conditions. Unraveling the mechanisms responsible for SND1 promoter regulation is of utmost interest to decipher the SND1 contribution in the realm of both normal and abnormal physiology.

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“…From the Protein-Protein interaction networks functional enrichment analysis through Online tools STRING and GeneMANIA, we figured out that SND1 and MAEL might be the target gene of PIWIL1 (53,54). The oncogene role of MAEL and SND1 have been shown to enhance the development and maintain the stemness of carcinoma (55)(56)(57)(58)(59)(60)(61). Furthermore, SND1 promoted the proliferation of cancer cells and regulated autophagy by activating NF−kB (62)(63)(64)(65)(66)(67).…”

Section: Discussionmentioning

confidence: 99%

PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population

et al. 2022

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As an important member of the Argonaute protein family, PIWI-like protein 1 (PIWIL1) plays a key role in tumor cell viability. However, the exact function of PIWIL1 in multiple myeloma (MM) and the underlying mechanism remain unclear. Here, we revealed that PIWIL1 was highly expressed in myeloma cell lines and newly diagnosed MM patients, and that its expression was notably higher in refractory/relapsed MM patients. PIWIL1 promoted the proliferation of MM cells and conferred resistance to chemotherapeutic agents both in vitro and in vivo. More importantly, PIWIL1 enhanced the formation of autophagosomes, especially mitophagosomes, by disrupting mitochondrial calcium signaling and modulating mitophagy-related canonical PINK1/Parkin pathway protein components. Mitophagy/autophagy inhibitors overcome PIWIL1-induced chemoresistance. In addition, PIWIL1 overexpression increased the proportion of side population (SP) cells and upregulated the expression of the stem cell-associated genes Nanog, OCT4, and SOX2, while its inhibition resulted in opposite effects. Taken together, our findings demonstrated that PIWIL1 induced drug resistance by activating mitophagy and regulating the MM stem cell population. PIWIL1 depletion significantly overcame drug resistance and could be used as a novel therapeutic target for reversing resistance in MM patients.

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The multifaceted oncogene SND1 in cancer: focus on hepatocellular carcinoma

Cited by 18 publications

References 59 publications

CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

Insights Into SND1 Oncogene Promoter Regulation

PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population

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