The multidrug and toxic compound extrusion (MATE) family in plants

Takanashi, Kojiro; Shitan, Nobukazu; Yazaki, Kazufumi

doi:10.5511/plantbiotechnology.14.0904a

Cited by 118 publications

(111 citation statements)

References 103 publications

(134 reference statements)

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“…The MATE family genes encode transporter proteins that transport organic acid molecules, such as citrate or malate, from root to soil, thus facilitating the chelation of the toxic Al ions. The most active tissue in which the MATE genes are highly transcribed is the root tip 11 .…”

Section: Resultsmentioning

confidence: 99%

“…The secretion of citrate is facilitated by HvAACT1 (Al-activated citrate transporter) gene encoding an enzyme in the multidrug and toxic compound extrusion (MATE) family 9,10 . MATE transporters occur widely in nature, transporting substrates such as organic acids, plant hormones and secondary metabolites in both prokaryotes and eukaryotes 11 . Homologous MATE proteins with similar citrate transport functions have been identified from wheat 12 , maize 13 , sorghum 14 , rice 15 , and Arabidopsis 16 .…”

Section: Introductionmentioning

confidence: 99%

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Genome-wide identification and transcriptional analyses of MATE transporter genes in root tips of wildCicerspp. under aluminium stress

Zhang¹,

Weir²,

Wei³

et al. 2020

Preprint

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26Chickpea is an economically important legume crop with high nutritional value in human diets. 27 Aluminium-toxicity poses a significant challenge for the yield improvement of this increasingly 28 popular crop in acidic soils. The wild progenitors of chickpea may provide a more diverse gene pool 29 for Al-tolerance in chickpea breeding. However, the genetic basis of Al-tolerance in chickpea and its 30 wild relatives remains largely unknown. Here, we assessed the Al-tolerance of six selected wild 31 Cicer accessions by measuring the root elongation in solution culture under control (0 µM Al 3+ ) and 32 Al-treatment (30 µM Al 3+ ) conditions. Al-treatment significantly reduced the root elongation in all 33 target lines compared to the control condition after 2-day's growth. However, the relative 34 reduction of root elongation in different lines varied greatly: 3 lines still retained significant root 35 growth under Al-treatment, whilst another 2 lines displayed no root growth at all. We performed 36 genome-wide identification of multidrug and toxic compound extrusion (MATE) encoding genes in 37 the Cicer genome. A total of 56 annotated MATE genes were identified, which divided into 4 major 38 phylogeny groups (G1-4). Four homologues to lupin LaMATE (> 50% aa identity; named CaMATE1-39 4) were clustered with previously characterised MATEs related to Al-tolerance in various other 40 plants. qRT-PCR showed that CaMATE2 transcription in root tips was significantly up-regulated 41 upon Al-treatment in all target lines, whilst CaMATE1 was up-regulated in all lines except Bari2_074 42 and Deste_064, which coincided with the lines displaying no root growth under Al-treatment. 43 Transcriptional profiling in five Cicer tissues revealed that CaMATE1 is specifically transcribed in the 44 root tissue, further supporting its role in Al-detoxification in roots. This first identification of MATE-45 encoding genes associated with Al-tolerance in Cicer paves the ways for future functional 46 characterization of MATE genes in Cicer spp., and to facilitate future design of gene-specific 47 markers for Al-tolerant line selection in chickpea breeding programs.48

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genome-wide identification and transcriptional analyses of MATE transporter genes in root tips of wildCicerspp. under aluminium stress

Zhang¹,

Weir²,

Wei³

et al. 2020

Preprint

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“…Another pleiotropic SNP at 109.65 cM on 3H is cosegregating with MATE efflux family (MATE; HORVU5Hr1G086830). MATE modulates abscisic acid efflux and ABA sensitivity responses to drought stress (Takanashi et al, ; Jarzyniak and Jasinski, ; Zhang et al, ). SNP ( BOPA2_12_11044) at 86 cM on 7H associated with the observed variations in the number of nodal roots is physically located in the domain of PPIB (HORVU7Hr1G095720).…”

Section: Discussionmentioning

confidence: 99%

Genetic components of root architecture and anatomy adjustments to water‐deficit stress in spring barley

Oyiga

Palczak

Wojciechowski

et al. 2019

Plant Cell & Environment

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Roots perform vital roles for adaptation and productivity under water‐deficit stress, even though their specific functions are poorly understood. In this study, the genetic control of the nodal‐root architectural and anatomical response to water deficit were investigated among diverse spring barley accessions. Water deficit induced substantial variations in the nodal root traits. The cortical, stele, and total root cross‐sectional areas of the main‐shoot nodal roots decreased under water deficit, but increased in the tiller nodal roots. Root xylem density and arrested nodal roots increased under water deficit, with the formation of root suberization/lignification and large cortical aerenchyma. Genome‐wide association study implicated 11 QTL intervals in the architectural and anatomical nodal root response to water deficit. Among them, three and four QTL intervals had strong effects across seasons and on both root architectural and anatomical traits, respectively. Genome‐wide epistasis analysis revealed 44 epistatically interacting SNP loci. Further analyses showed that these QTL intervals contain important candidate genes, including ZIFL2, MATE, and PPIB, whose functions are shown to be related to the root adaptive response to water deprivation in plants. These results give novel insight into the genetic architectures of barley nodal root response to soil water deficit stress in the fields, and thus offer useful resources for root‐targeted marker‐assisted selection.

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“…MATEs involved in xenobiotic detoxification accept a wide range of substrates, but some MATEs have narrower substrate specificities; for example, some MATEs from plants accept citrate, salicylic acid, or flavonoids as substrates (Durrett et al 2007;Serrano et al 2013;Zhao and Dixon 2010). Recent research has revealed the functions of many MATEs in plants (Shoji 2014;Takanashi et al 2014;Yazaki et al 2008).…”

Section: Transporter Familiesmentioning

confidence: 99%

Alkaloid transporters in plants

Shitan

Kato

Shoji

2014

Plant Biotechnology

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Plants produce a multitude of secondary metabolites, including alkaloids with biological activities, and many alkaloids have been used for medicinal purposes. The biosynthetic enzymes and genes involved in alkaloid metabolic pathways exhibit divergent localizations, implying that alkaloid metabolites, including pathway products and intermediates, travel from organelle to organelle, cell to cell, and organ to organ. Biochemical studies have indicated that specific transporters move these metabolites. Indeed, molecular and cellular approaches have identified alkaloid transporters of the ATP-binding cassette (ABC) protein, multidrug and toxic compound extrusion (MATE), and purine permease (PUP) families. Interestingly, some of these transporters were found to be required for the efficient biosynthesis of alkaloids in plants. Here, we provide an updated inventory of alkaloid transporters and discuss the possibility of genetically manipulating the expression of these transporters to increase the accumulation of valuable alkaloid compounds.

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The multidrug and toxic compound extrusion (MATE) family in plants

Cited by 118 publications

References 103 publications

Genome-wide identification and transcriptional analyses of MATE transporter genes in root tips of wildCicerspp. under aluminium stress

Genome-wide identification and transcriptional analyses of MATE transporter genes in root tips of wildCicerspp. under aluminium stress

Genetic components of root architecture and anatomy adjustments to water‐deficit stress in spring barley

Alkaloid transporters in plants

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