The multidisciplinary evaluation of the atypical dementia patient

Geschwind, Michael D.; Belkoura, Caroline Racine

doi:10.1002/9781118797662.ch2

Cited by 2 publications

(5 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, cognitive deficits outlining a hippocampal pattern (poor recall, flat learning curve, and poor recognition) along with language and visuospatial skills impairment are pathognomonic for AD. 17,18 Patients with AD forget new information rapidly and do not benefit from cues; list-learning tasks are most sensitive for detecting the memory deficits in early AD. 19 Patients with the behavioral variant of frontotemporal dementia (bvFTD) or frontal AD variant (also known as behavioral dysexecutive AD variant) show profound executive dysfunction.…”

Section: Diagnostic Workupmentioning

confidence: 99%

“…19 Patients with the behavioral variant of frontotemporal dementia (bvFTD) or frontal AD variant (also known as behavioral dysexecutive AD variant) show profound executive dysfunction. 17,18,20 Individuals with movement disorders such as Parkinson's disease (PD) or Huntington's disease (HD) demonstrate a frontal-subcortical deficit pattern, with executive dysfunction and poor spontaneous recall, but generally preserved learning and intact recognition (cues help). 17,21 Mixed major NCDs such as dementia with Lewy bodies (DLB) and fragile X-associated tremor/ataxia syndrome (FXTAS) combine hippocampal and frontal deficit patterns.…”

Section: Diagnostic Workupmentioning

confidence: 99%

“…17,18,20 Individuals with movement disorders such as Parkinson's disease (PD) or Huntington's disease (HD) demonstrate a frontal-subcortical deficit pattern, with executive dysfunction and poor spontaneous recall, but generally preserved learning and intact recognition (cues help). 17,21 Mixed major NCDs such as dementia with Lewy bodies (DLB) and fragile X-associated tremor/ataxia syndrome (FXTAS) combine hippocampal and frontal deficit patterns. 18,22,23 Depression is often associated with neurodegenerative diseases such as AD, PD, and HD.…”

Section: Diagnostic Workupmentioning

confidence: 99%

“…Systemic Medical Diseases, Substances, and Medications Associated with Psychotic Symptoms in Older Adults 4,11,17,25,[28][29][30][32][33][34][35][36][37][38][39][40][41][42]. …”

mentioning

confidence: 99%

See 3 more Smart Citations

Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review

Seritan

2023

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

Background: Approximately 15% of older adults may experience psychotic phenomena. Primary psychiatric disorders that manifest with psychosis (delusions, hallucinations, and disorganized thought or behavior) account for less than half. Up to 60% of late-life psychotic symptoms are due to systemic medical or neurological conditions, particularly neurodegenerative diseases. A thorough medical workup including laboratory tests, additional procedures if indicated, and neuroimaging studies is recommended. This narrative review summarizes current evidence regarding the epidemiology and phenomenology of psychotic symptoms encountered as part of the neurodegenerative disease continuum (including prodromal and manifest stages). Results: Prodromes are constellations of symptoms that precede the onset of overt neurodegenerative syndromes. Prodromal psychotic features, particularly delusions, have been associated with an increased likelihood of receiving a neurodegenerative disease diagnosis within several years. Prompt prodrome recognition is crucial for early intervention. The management of psychosis associated with neurodegenerative diseases includes behavioral and somatic strategies, although evidence is scarce and mostly limited to case reports, case series, or expert consensus guidelines, with few randomized controlled trials. Conclusion: The complexity of psychotic manifestations warrants management by interprofessional teams that provide coordinated, integrated care.

show abstract

Section: Diagnostic Workupmentioning

confidence: 99%

Section: Diagnostic Workupmentioning

confidence: 99%

Section: Diagnostic Workupmentioning

confidence: 99%

“…Systemic Medical Diseases, Substances, and Medications Associated with Psychotic Symptoms in Older Adults 4,11,17,25,[28][29][30][32][33][34][35][36][37][38][39][40][41][42]. …”

mentioning

confidence: 99%

See 2 more Smart Citations

Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review

Seritan

2023

J Geriatr Psychiatry Neurol

View full text Add to dashboard Cite

show abstract

“…Pada pasien apraksia berbicara yang progresif, agramatika primary progressive aphasia (PPA), ataupun keduanya, kelainannya pada area Broca. 12,13 Pencitraan Fungsional Pencitraan fungsional FTD akan menunjukkan hipoperfusi frontal atau hipometabolisme pada SPECT dan PET. PET dapat digunakan untuk evaluasi glukosa otak atau metabolisme oksigen sebagai tanda aktivitas sel, sedangkan SPECT memberikan informasi aliran darah otak/perfusi otak.…”

Section: Demensia Frontotemporal Karakteristik Klinisunclassified

Manifestasi Klinis dan Gambaran Pencitraan Struktural dan Fungsional Berbagai Subtipe Demensia

Tjandra Dewi,

Laksmidewi

2023

Cermin Dunia Kedokteran

View full text Add to dashboard Cite

Dementia causes impaired cognition, behavior, and daily functional activities with physical, mental, and psychosocial consequences for patients, families, and communities. However, dementia diagnosis is still challenging. Classification of dementia subtypes also requires structuraland functional imaging studies. The structural imaging needed to support Alzheimer’s dementia and vascular dementia diagnosis is brain magnetic resonance imaging (MRI), frontotemporal dementia diagnosis can be supported by brain MRI or functional imaging, while Lewy Body dementia diagnosis requires functional imaging and biomarkers findings.

show abstract

The multidisciplinary evaluation of the atypical dementia patient

Cited by 2 publications

References 69 publications

Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review

Advances in the Diagnosis and Management of Psychotic Symptoms in Neurodegenerative Diseases: A Narrative Review

Manifestasi Klinis dan Gambaran Pencitraan Struktural dan Fungsional Berbagai Subtipe Demensia

Contact Info

Product

Resources

About