The Mugello Study, a survey of nonagenarians living in Tuscany: Design, methods and participants' general characteristics

Molino-Lova, Raffaele; Sofi, Francesco; Pasquini, Guido; Gori, Anna Maria; Vannetti, Federica; Abbate, Rosanna; Gensini, Gian Franco; Macchi, Claudio

doi:10.1016/j.ejim.2013.09.008

Cited by 38 publications

(41 citation statements)

References 35 publications

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“…The analysis presented in this paper is based upon data from the Mugello Study, a survey on nonagenarians living in the Mugello area, north-eastward of Florence, in Tuscany, Italy, whose detailed description is reported elsewhere [ 15 ]. Briefly, all community dwelling persons aged 90 + living in the Mugello area who accepted to be enrolled, underwent a structured interview and medical visit, along with a series of instrumental assessments at their home.…”

Section: Methodsmentioning

confidence: 99%

“…Level of physical activity (SPA) was investigated and scored by administering a questionnaire to each nonagenarian. This questionnaire, which has been described elsewhere was modeled on the Harvard Alumni Questionnaire, and adapted for Italian people [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…The Mugello Study [ 15 ] is a clinical epidemiologic survey of nonagenarians living in the Mugello area, north-eastward of Florence, Tuscany, Italy. This area is characterized by a higher percentage of nonagenarians with respect to the entire population, 1.76%, compared to the Italian reference value, 1.14% (ISTAT—Data 2015).…”

Section: Introductionmentioning

confidence: 99%

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Hemoglobin concentration is associated with self-reported disability and reduced physical performance in a community dwelling population of nonagenarians: the Mugello Study

et al. 2017

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People aged 90 and older represent a fast-growing population segment who deserve specific attention and research. Aging is associated with a progressive decrease in hemoglobin concentration, which predicts adverse outcome, such as mortality, morbidity, frailty and disability. Whether this association is independent from increased prevalence of comorbidity, causing both anemia and reduced physical function is yet under debate. The aim of this study is to explore the relationship between hemoglobin concentration and self-reported disability and reduced physical performance in a community dwelling population of nonagenarians. Data presented were collected in the framework of the Mugello Study, a clinical epidemiologic survey of nonagenarians living in the Mugello area (Tuscany, Italy). 251 persons (177 women, age 93.2 ± 3.3 years; 74 men, age 92.2 ± 2.5 years) underwent a blood draw. Along with hemoglobin concentration, self-reported disability (basic and instrumental activities of daily living), physical performance (Short Physical Performance Battery), self-reported physical activity and muscular strength (handgrip measurement) were assessed. Covariates, inherent sociodemographic and health indicators and comorbidities were also included in the analysis. This study confirms that anemia is very common in the oldest old, with a significantly higher prevalence in males (50% in men vs 24% in women). Multiple linear regression analysis, including all the comorbid conditions as confounding factors, shows that hemoglobin concentration is independently associated with handgrip strength, self-reported physical activity and disability in dressing, and taking a shower/bath. In conclusion, results from this study confirm that in the oldest old, low hemoglobin concentration is strongly associated with self-reported disability and decline of physical performance independent of comorbidity.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Hemoglobin concentration is associated with self-reported disability and reduced physical performance in a community dwelling population of nonagenarians: the Mugello Study

et al. 2017

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“…Results presented are based on data from the Mugello study, an epidemiologic, retrospective, single-center study on a large number of oldest old living in the Mugello area, whose details have been previously described [11]. In this survey, subjects have been evaluated for various health issues, including presence and extent of diseases, aspects related to nutritional status and routine hematology and biochemistry, and data collected in the Mugello Study database.…”

Section: Participantsmentioning

confidence: 99%

“…Circadian rhythm alteration (sCR) was defined according to presence of insomnia, irregular sleep-wake pattern, advanced sleep phase syndrome. Comorbid conditions, such as diabetes, hypertension, dyslipidemia -among others, were also considered as dichotomy variables and ascertained according to pre-established algorithms that combined information gathered from medical history, medical records, clinical examination and the blood and instrumental tests included in the Mugello study protocol [11].…”

Section: Participantsmentioning

confidence: 99%

Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

et al. 2018

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Gender effect on well-being of the oldest old: a survey of nonagenarians living in Tuscany: the Mugello study

et al. 2018

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The population of industrialized nations is progressively aging, with Italy having one of the most elderly populations in the world. Natural aging may be associated with physical and cognitive impairments, often straining public resources. The present study aims to investigate the influence of gender on wellness of the nonagenarians. We evaluated quality of life among nonagenarians living in the Mugello area, an Italian location with a large population of individuals > 90 years, using the Health Survey Scoring SF-12. The 15-item Geriatric Depression Scale and Basic and Instrumental Activity of Daily Living scales were also assessed. The Mini-Mental State Examination was used to evaluate the cognitive status. In the current survey, women outnumbered men 2.7:1 confirming their higher longevity. However, on the basis of SF-12 scores, nonagenarian women felt worse than men, both physically (mean: women = 41.8 vs men = 44.4, p = 0.004) and mentally (mean: women = 46.7 vs men =48.5, p = 0.034), and their depression rates were higher: considering a General Depression Scale score ≥ 5 as a possible depression status; 37.5% of men reported depression vs. 48.5% of women (p = 0.021). Significant differences were observed also in daily activities, both basic (median: woman = 3 vs men = 5, p < 0.001) and instrumental (median woman = 1 vs me = 3, p < 0.001). Despite prior reports showing that women perform better than men in aging, our study confirms data reported in most national and European surveys: women live longer than men, but with poorer quality of life. The current study confirms the phenomenon known as the "male-female health-survival paradox."

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The Mugello Study, a survey of nonagenarians living in Tuscany: Design, methods and participants' general characteristics

Cited by 38 publications

References 35 publications

Hemoglobin concentration is associated with self-reported disability and reduced physical performance in a community dwelling population of nonagenarians: the Mugello Study

Hemoglobin concentration is associated with self-reported disability and reduced physical performance in a community dwelling population of nonagenarians: the Mugello Study

Relationship between Inflammatory Parameters and Cardiovascular and Lifestyle Factors in the Mugello Study Oldest Old

Gender effect on well-being of the oldest old: a survey of nonagenarians living in Tuscany: the Mugello study

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