The mucoproteins of the nasal mucosa of allergic patients before and after treatment with corticotropin

Allergic asthma in childhood.

“…Defects in some regulator mechanism necessary to maintain a balanced function; changes in the bronchial ground substance (Rappaport et al, 1953), or changed permeability conditions there (McCarter and Vazquez, 1966;Samter, 1959); pathological reactivity of 3-adrenergic or cholinergic receptors in the bronchi (Kirkpatrick and Keller, 1967;Ouellette and Reed, 1965); or imbalance of local enzyme systems (Ann. Allergy, 1965;Ungar and Hayashi, 1958) all merit attention in this challenging field.…”

Antiasthmatic Drugs I

“…This abnormality is reversed with corticotrophin treatment (Rappaport et al 1953). Allergic individuals show a decrease in glycoprotein staining of connective tissue cells, and basement membrane of surface epithelium capillaries and glands.…”

XXXVII Histochemical Studies of the Pathogenesis of Nasal Polyps

“…4 In the turbinates, loss of basement membrane was reported consistently in the allergic state. 17 The exact site of origin of these polyps was not recorded at the time of operation. No further information regarding the epithelial cells was derived from the histochemical studies.…”