The Mucopolysaccharide Content of the Skin in Localized (Pretibial) Myxedema

Increased urinary excretion of acidic mucopolysaccharides in exophthalmos

“…Metachromatic substance is also found in connective tissue, lacrymal glands, and muscles under the sarcolemnal membrane. Similar changes are found in the affected skin of patients with localized myxoedema, a condition often associated with infiltrative exophthalmos (3,4). Increased mucopolysaccharide measured chemically is found in the area of the lesion and also in clinically uninvolved skin (5).…”

Mucopolysaccharide Content of Skin in Patients With Pretibial Myxedema*†

“…They found considerably less of this material in skin from the amputated leg of an elderly man (4). We …”

Exophthalmus-Myxoedema Circumscriptum Praetibiale-Osteoarthropathia Hypertrophicans (E. M. O.) Syndrome in Graves' Disease: A Review of Eight Cases Reported in Japan

“…It is well known that the cutaneous change in pretibial myxedema consists of the deposition of mutinous material throughout the dermis. Watson and Pearce (1949), in chemical analysis of whole skin from pretibial myxedema found an increased amount of hyaluronic acid, and to a lesser extent, chondroitin sulfate. On the contrary, Schiller et al (1962), in chemical analysis of skin in hypothyroid rats, found that the myxedematous tissue had an increased concentration of hyaluronic acid and a decreased amount of chondroitin sulfate B.…”