The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems

Sarparanta, Mirkka; Bimbo, Luís M.; Mäkilä, Ermei; Salonen, Jarno; Laaksonen, Päivi; Helariutta, K.; Linder, Markus B.; Hirvonen, Jouni; Laaksonen, Timo; Santos, Hélder A.; Airaksinen, Anu J.

doi:10.1016/j.biomaterials.2012.01.029

Cited by 127 publications

(94 citation statements)

References 48 publications

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“…Some researchers from VTT use a transformant strain of fungi to produce Class II hydrophobin [29, [63][64][65][66]. After the fermentation process, a chemical surfactant, e.g.…”

Section: Hydrophobin Separation By Phase Partitioningmentioning

confidence: 99%

Recent Advances in Fungal Hydrophobin Towards Using in Industry

2015

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Fungal hydrophobin is a family of low molecular weight proteins consisting of four disulfide bridges and an extraordinary hydrophobic patch. The hydrophobic patch of hydrophobins and the molecules of gaseous CO2 may interact together and form the stable CO2-nanobubbles covered by an elastic membrane in carbonated beverages. The nanobubbles provide the required energy to provoke primary gushing. Due to the hydrophobicity of hydrophobin, this protein is used as a biosurfactant, foaming agent or encapsulating agent in food products and medicine formulations. Increasing demands for using of hydrophobins led to a challenge regarding production and purification of this product. However, the main issue to use hydrophobin in the industry is the regulatory affairs: yet there is no approved legislation for using hydrophobin in food and beverages. To comply with the legislation, establishing a consistent method for obtaining pure hydrophobins is necessary. Currently, few research teams in Europe are focusing on different aspects of hydrophobins. In this paper, an up-to-date collection of highlights from those special groups about the bio-chemical and physicochemical characteristics of hydrophobins have been studied. The recent advances of those groups concerning the production and purification, positive applications and negative function of hydrophobin are also summarised.

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“…Some researchers from VTT use a transformant strain of fungi to produce Class II hydrophobin [29, [63][64][65][66]. After the fermentation process, a chemical surfactant, e.g.…”

Section: Hydrophobin Separation By Phase Partitioningmentioning

confidence: 99%

Recent Advances in Fungal Hydrophobin Towards Using in Industry

2015

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“…1,3,[26][27][28][29][30][31][32][33][34][35][36] The PSi materials have been loaded with different drug/protein molecules to modulate their solubility and to control the drug release, showing also their markedly biocompatible characteristics, concurrently serving also as diagnostic imaging tools. 3,[37][38][39][40][41][42][43][44][45][46][47][48][49][50] For example, the PSi quantum sponge structure 51 provides tunable photonic properties for biomedical diagnostics, 34,52 and infrared photoluminescence. This feature has allowed PSi vectors to be exploited to assess their fate on systemic administration.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured porous silicon in preclinical imaging: Moving from bench to bedside

et al. 2012

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Advances in nanotechnology have prompted rapid progress and versatile imaging modalities for diagnostics and treatment of diseases. Molecular imaging is a powerful technique for quantifying physiological changes in vivo using noninvasive imaging probes. These probes are used to image specific cells and tissues within a whole organism. Currently, imaging is an essential part of clinical protocols providing morphological, structural, metabolic and functional information. Using theranostic micro-or nanoparticles, which combine both therapeutic and diagnostic capabilities in one single entity, holds a true promise to propel the biomedical field toward personalized medicine. With this approach, biological processes can be directly and simultaneously monitored with the treatment of the diseases. This mini-review highlights the recent innovative diagnostic imaging aspects of porous silicon (PSi) materials and emphasizes their potential as theranostic platforms and tools for the clinic. Multiple biomedical imaging applications of the PSi materials are also outlined.

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“…In fact, impediments to intestinal absorption, such as poor solubility and instability in gastrointestinal conditions, are associated with many drugs and restrict their oral bioavailability. Drug delivery systems hold great promise in solving these problems, but their effectiveness might be limited by their often rapid transit through the gastrointestinal tract [13].…”

Section: Introductionmentioning

confidence: 99%