volume 315, issue 2, PG195-G205 2018
DOI: 10.1152/ajpgi.00264.2017
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Abstract: Paneth cells are a key subset of secretory epithelial cells found at the base of small intestinal crypts. Unlike intestinal goblet cells, which secrete the mucin Muc2, Paneth cells are best known for producing an array of antimicrobial factors. We unexpectedly identified Muc2 staining localized around Paneth cell granules. Electron microscopy (EM) confirmed an electron lucent halo around these granules, which was lost in Paneth cells from Muc2-deficient () mice. EM and immunostaining for lysozyme revealed that…

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