The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: A meta-analysis

Liu, Hua; Yang, Min; Li, Guangming; Qiu, Ya; Zheng, Jie; Du, Xin; Wang, Jiliang; Liu, Ruo-Wei

doi:10.1016/j.jns.2010.04.001

Cited by 38 publications

(24 citation statements)

References 50 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MTHFR gene C677T polymorphism (MTHFR C677T) causes an amino-acid change from alanine to valine and results in the enzyme becoming thermolabile and half decreased activity. 1 This polymorphism is the most common genetic cause of hyperhomocysteinemia, 2 which may causally associate with diseases, such as birth defects, [3][4][5] cardiovascular disease, 6,7 schizophrenia and Alzheimer's disease. 8 Interestingly, this polymorphism is associated with elevated homocysteine levels only in cases of low folic acid intake.…”

Section: Introductionmentioning

confidence: 99%

Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

et al. 2012

View full text Add to dashboard Cite

The methylenetetrahydrofolic acid reductase (MTHFR) C677T polymorphism causes an amino-acid change from alanine to valine and results in the enzyme becoming thermolabile and half decreased activity. Its prevalence varies among global population. We collected data about MTHFR C677T polymorphism prevalence from epidemiology studies, as well as ultraviolet (UV) radiations and some other climatological factors from the internet. The results of the correlation and quadric regression showed that there was inverse U-shape relationship between T allele frequency and UV radiation. The explanatory power of UV radiation was stronger than latitude and all climatological factors. Our results supported the hypothesis that the distribution pattern of MTFHR C677T polymorphism in Eurasia might be the result of interaction of genetic and environmental natural selection, especially the UV radiation.

show abstract

Section: Introductionmentioning

confidence: 99%

Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Meta-analysis is usually used to combine comparative studies to enlarge the sample size and statistical power and reach more obvious conclusion. Numerous meta-analyses were published considering MTHFR C677T polymorphism as risk for several diseases like-neural tube defects [40], Down syndrome [41], cleft lip with/without palate [42], recurrent pregnancy loss [43], stroke [44], schizophrenia [45], bipolar [46], depression [45], migraine [47] and vascular dementia [48] etc.…”

Section: Discussionmentioning

confidence: 99%

Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population

Rai

2015

Ind J Clin Biochem

View full text Add to dashboard Cite

The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to Alzheimers disease (AD) was controversial in previous studies. The present meta-analysis was designed to investigate the association of MTHFR C677T polymorphism with AD. Nine studies were identified by search of PubMed, Google Scholar, Elsevier, Springer Link databases, up to January 2013. Odds ratios (ORs) with corresponding 95 % confidence interval (CI) were calculated using fixed effects model or random effects model. All statistical analysis was done by Mix version 1.7. MTHFR C677T polymorphism had a significant association with susceptibility to AD in all genetic models (for T vs C: OR 1.29, 95 % CI 1.15-1.44, p \ 0.0001; for TT ? CT vs CC: OR 1.38, 95 % CI 1.16-1.364, p = 0.0002; for TT vs CC: OR 1.60, 95 % CI 1.25-2.04, p = 0.0001; for CT vs CC: OR 1.28, 95 % CI 1.1-1.53, p \ 0.008; for TT vs CT ? CC: OR 1.37, 95 % CI 1.12-1.67, p = 0.002). Results from present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD in Asian population.

show abstract

“…Alzheimer is the first common cause of dementia [1]. Classification of Alzheimer's disease (AD) into subtypes based on the time of onset of the symptoms is still controversial.…”

Section: Introductionmentioning

confidence: 99%

C677T and A1298C gene polymorphisms and sporadic early-onset Alzheimer’s disease

Mansouri¹,

Klai²,

Fekih-Mrissa³

et al. 2013

AAD

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. Although the clinical manifestations and the pathological features have been well elucidated, a clear etiology of AD is still unknown to this day. In the past few decades, investigations have elucidated that both the genetic and the environmental factors are capable of causing the development of AD. We report a patient with clinically diagnosed earlyonset Alzheimer's disease, age of onset 45 years. Genetic analysis revealed two MTHFR heterozygous polymorphisms C677T and A1298C.

show abstract

The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: A meta-analysis

Cited by 38 publications

References 50 publications

Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

Is the prevalence of MTHFR C677T polymorphism associated with ultraviolet radiation in Eurasia?

Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population

C677T and A1298C gene polymorphisms and sporadic early-onset Alzheimer’s disease

Contact Info

Product

Resources

About