The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p

Tan, W. Y.; Zolotukhin, Andrei S.; Bear, Jenifer; Patenaude, Daniel J.; Felber, Barbara K.

doi:10.1017/s1355838200000832

Cited by 95 publications

(96 citation statements)

References 37 publications

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“…Nuclear export of RNA Nuclear export of most mRNAs relies on NXF-1/TAP and HEL-1/UAP56 (Tan et al 2000;MacMorris et al 2003), whereas XPO-1 is responsible for export of other RNA polymerase II-transcribed genes, such as small nuclear RNAs, premicro RNAs (pre-miRNAs), and certain mRNAs. The best-characterized miRNA in C. elegans is let-7, which controls developmental timing.…”

Section: Nuclear Localization and Nuclear Export Signalsmentioning

confidence: 99%

Cell Biology of theCaenorhabditis elegansNucleus

Cohen-Fix

Askjaer

2017

Genetics

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Studies on the Caenorhabditis elegans nucleus have provided fascinating insight to the organization and activities of eukaryotic cells. Being the organelle that holds the genetic blueprint of the cell, the nucleus is critical for basically every aspect of cell biology. The stereotypical development of C. elegans from a one cell-stage embryo to a fertile hermaphrodite with 959 somatic nuclei has allowed the identification of mutants with specific alterations in gene expression programs, nuclear morphology, or nuclear positioning. Moreover, the early C. elegans embryo is an excellent model to dissect the mitotic processes of nuclear disassembly and reformation with high spatiotemporal resolution. We review here several features of the C. elegans nucleus, including its composition, structure, and dynamics. We also discuss the spatial organization of chromatin and regulation of gene expression and how this depends on tight control of nucleocytoplasmic transport. Finally, the extensive connections of the nucleus with the cytoskeleton and their implications during development are described. Most processes of the C. elegans nucleus are evolutionarily conserved, highlighting the relevance of this powerful and versatile model organism to human biology.KEYWORDS Caenorhabditis elegans; chromatin; gene expression; lamin; LEM-domain proteins; LINC; P granule; nuclear pore complex; nuclear envelope; nucleocytoplasmic transport; nucleolus; WormBook TABLE OF CONTENTSAbstract 25 C. elegans as a model system to study cell biology of the nucleus 26 Structural components of the nucleus 27

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Section: Nuclear Localization and Nuclear Export Signalsmentioning

confidence: 99%

Cell Biology of theCaenorhabditis elegansNucleus

Cohen-Fix

Askjaer

2017

Genetics

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“…[17][18][19][20][21][22] Other studies suggest that the role of NUP98 in RNA transport may be mediated by TAP (TIP associated protein), a novel cellular factor first identified for its interaction with TIP (tyrosine kinase-interacting protein) (Figure 1a). [30][31][32] TAP is required for export of cellular mRNA substrates. The glutamine-rich C-terminal domain of TAP interacts with the FG repeats of NUP98.…”

Section: Figurementioning

confidence: 99%

NUP98 gene fusions in hematologic malignancies

Lam

Aplan

2001

Leukemia

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Acute leukemia is associated with a wide spectrum of recurrent, non-random chromosomal translocations. Molecular analysis of the genes involved in these translocations has led to a better understanding of both the causes of chromosomal rearrangements as well as the mechanisms of leukemic transformation. Recently, a number of laboratories have cloned translocations involving the NUP98 gene on chromosome 11p15.5, from patients with acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML), and T cell acute lymphoblastic leukemia (T-ALL). To date, at least eight different chromosomal rearrangements involving NUP98 have been identified. The resultant chimeric transcripts encode fusion proteins that juxtapose the N-terminal GLFG repeats of NUP98 to the C-terminus of the partner gene. Of note, several of these translocations have been found in patients with therapy-related acute myelogenous leukemia (t-AML) or myelodysplastic syndrome (t-MDS), suggesting that genotoxic chemotherapeutic agents may play an important role in generating chromosomal rearrangements involving NUP98. Leukemia (2001) 15, 1689-1695.

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“…TAP, which itself facilitates the nuclear export of cellular mRNA (45,46), heterodimerizes with p15 that further stimulates mRNP export (47,48). TAP proteins represent a class of nuclear transport receptors that, via an essential C-terminal domain, directly interact with nucleoporin components of the NPC (49 -51).…”

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confidence: 99%

The Evolutionarily Conserved Kaposi's Sarcoma-associated Herpesvirus ORF57 Protein Interacts with REF Protein and Acts as an RNA Export Factor

Malik¹,

Blackbourn

Clements

2004

Journal of Biological Chemistry

138

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shown to function as a CRM1-independent nuclear mRNA export factor, promoting export of mRNAs that are poor substrates for splicing. The ␥-herpesvirus ORF57 protein, and its ␣-1 herpesvirus ICP27 counterpart both export RNA through pathways involving REF and TAP proteins, although divergence of these herpesvirus subfamilies occurred some 180 -210 million years ago. The TAP-mediated cellular mRNA export pathway is CRM1-independent. However, human immunodeficiency virus type 1 Rev protein-mediated RNA export, which is CRM1-dependent, was considerably inhibited by ORF57, suggesting that Rev and ORF57 compete for a common export component. These data strengthen arguments that TAP and CRM1 pathways converge in accessing similar components of the nuclear pore complex. We propose that ORF57-mediated RNA export may use different export factors to accommodate the KSHV-infected host cell environments, for example, in B-cells or endothelial cells and during the different phases of lytic virus replication.

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The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p

Cited by 95 publications

References 37 publications

Cell Biology of theCaenorhabditis elegansNucleus

Cell Biology of theCaenorhabditis elegansNucleus

NUP98 gene fusions in hematologic malignancies

The Evolutionarily Conserved Kaposi's Sarcoma-associated Herpesvirus ORF57 Protein Interacts with REF Protein and Acts as an RNA Export Factor

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