The MRI-detected osteophyte score is a predictor for undergoing joint replacement in patients with end-stage knee osteoarthritis

Liu, Lizu; Ishijima, Muneaki; Kaneko, Haruka; Sadatsuki, R.; Hada, S.; Kinoshita, M.; Aoki, Takako; Futami, I.; Yusup, A.; Arita, Hitoshi; Shiozawa, Jun; Takazawa, Yuji; Ikeda, Hiroshi

doi:10.1080/14397595.2016.1206509

Cited by 13 publications

(12 citation statements)

References 41 publications

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“…To the best of our knowledge, there are only two longitudinal studies examining the associations of MRI-defined OPs with knee structural changes so far. While one did not find any significant associations between MRI-defined OPs and knee structural progression 11 , another reported that MRI-defined OP was an important factor in determining future total knee arthroplasty 36 . Our findings from the current longitudinal study were consistent, with OPs detected only by MRI but not by X-ray (MRI-OPs) being associated with increases in cartilage defects/loss and subchondral bone abnormalities over time.…”

Section: Discussionmentioning

confidence: 92%

Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study

Zhu

Laslett

Han

et al. 2017

Osteoarthritis and Cartilage

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Section: Discussionmentioning

confidence: 92%

Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study

Zhu

Laslett

Han

et al. 2017

Osteoarthritis and Cartilage

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“…On the other hand, such formation in the knee has been reported to increase pain and the rate of incidence of TKA surgery. 19 It is anticipated that the number of patients using biological DMARDs will substantially increase in the future. Considering that the incidence of joint replacement surgery has not decreased since introduction of biological DMARDs, 20 it is a possible that RA patients undergoing joint replacement surgery for secondary OA will continue to increase.…”

Section: Discussionmentioning

confidence: 99%

Effects of malalignment and disease activity on osteophyte formation in knees of rheumatoid arthritis patients

Okumura

Kawasaki

Kubo

et al. 2020

J Orthop Surg (Hong Kong)

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Purpose: Rheumatoid arthritis (RA) patients with secondary osteoarthritis (OA) in a knee joint following a total knee arthroplasty (TKA) procedure have been increasing. Here, we investigated osteophyte formation in knee joints of RA patients and associated factors. Methods: We retrospectively examined findings of 35 knees in 30 RA patients (26 females, 4 males; mean age: 63.0 years; median disease duration: 15 years) who underwent TKA, including preoperative anteroposterior view radiographs of the knee joint. Using the ImageJ software package, osteophyte size in the medial femur (MF), medial tibia (MT), lateral femur (LF), and lateral tibia (LT) regions was also determined. Results: The mean femorotibial angle was 179°, while Larsen grade was 2 in 1, 3 in 12, 4 in 18, and 5 in 2 patients. Osteophyte sizes in the MF, MT, LF, and LT regions were 37.2, 17.0, 27.2, and 4.57 mm2, respectively, and significantly greater in the medial compartment (MC; MF+MT) than the lateral compartment (LC; LF+LT) ( p < 0.001). In varus cases, osteophyte size in the MC was significantly larger than normal and valgus cases ( p = 0.0016). Furthermore, osteophyte size in the MC was negatively correlated with the inflammatory markers C-reactive protein ( r = −0.492, p = 0.0027) and erythrocyte sedimentation rate ( r = −0.529, p = 0.0016), whereas that in the LC was negatively correlated with disease activity ( r = −0.589, p = 0.0023). Conclusion: Our results suggest that alignment and disease activity influence osteophyte formation in RA patients, with secondary OA a more prominent symptom in RA patients with controlled inflammation.

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“…Our study found that BMLs, cartilage defects, meniscal extrusion, IPFP abnormality and effusion-synovitis were the structural risk factors for worsening MRI-detected OP, suggesting that MRI-detected OP could be a result of other osteoarthritic structural abnormalities. On the other hand, it should be noted that MRI-detected OPs were also found to consistently and independently predict changes in knee cartilage, BMLs and cartilage volume, and the need to undergo total knee replacement (TKA) [ 13 , 15 ]. It is thought that subchondral bone expansion leads to splitting of cartilage and is potentially a precursor to formation of cartilage defects [ 22 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hakky et al measured OP volume using MRI and observed significant positive correlation between OP volume and cartilage thickness loss [ 16 ]. In the latest study, MRI-detected OPs in a group of patients with end-stage OA scored using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) grading system, those with a MRI-detected OP score of more than 30 have about threefold higher risk of undergoing total knee arthroplasty [ 15 ]. Based on the Chingford study, the natural history of radiographic OA is that of very slow progression [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

MRI-detected osteophytes of the knee: natural history and structural correlates of change

et al. 2018

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BackgroudThe natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-detected OP change over time. Thus, the aim of current study is to describe the natural history of knee MRI-detected OP, and to determine if knee structural abnormalities are associated with change of MRI-detected OP in a longitudinal study of older adults.MethodsRandomly selected older adults (n = 837, mean age 63 years) had MRI at baseline and 413 of them had MRI 2.6 years later to measure MRI-detected OP, cartilage defects, cartilage volume, bone marrow lesions (BMLs), meniscal extrusion, infrapatellar fat pad (IPFP) quality score/maximum area and effusion-synovitis.ResultsOver 2.6 years, average MRI-detected OP score increased significantly in all compartments. The total MRI-detected OP score remained stable in 53% of participants, worsened (≥ 1-point increase) in 46% and decreased in 1%. Baseline cartilage defects (RR, 1.25–1.35), BMLs (RR, 1.16–1.17), meniscal extrusion (RR, 1.22–1.33) and IPFP quality score (RR, 1.08–1.20) site-specifically and independently predicted an increase in MRI-detected OP (p values all ≤ 0.05), after adjustment for covariates. Presence of IPFP abnormality was significantly associated with increased MRI-detected OPs but became non-significant after adjustment for other structural abnormalities. Total (RR, 1.27) and suprapatellar pouch effusion-synovitis (RR, 1.22) were both associated with increased MRI-detected OPs in the lateral compartment only (both p < 0.04).ConclusionKnee MRI-detected OPs are common in older adults and are likely to progress. The association between baseline structural abnormalities and worsening MRI-detected OPs suggest MRI-detected OP could be a consequence of multiple knee structural abnormalities.

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The MRI-detected osteophyte score is a predictor for undergoing joint replacement in patients with end-stage knee osteoarthritis

Abstract: The osteophyte score detected by MRI, in addition to ADL score, was found to be an important factor in determining whether the patient should undergo TKA.

Cited by 13 publications

References 41 publications

Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study

Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study

Effects of malalignment and disease activity on osteophyte formation in knees of rheumatoid arthritis patients

MRI-detected osteophytes of the knee: natural history and structural correlates of change

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