The MRE11 opposes white spot syndrome virus infection through the IRF and Dorsal mediated antiviral pathways in shrimp

Zhu, Peng; Yan, Xuheng; Jiang, Xiewu; Li, Hui; Chen, Rongjian; Wang, Sheng; Li, Chaozheng

doi:10.1016/j.fsi.2022.05.054

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…An IRF‐Vago‐JAK/STAT axis similar to the IRF‐IFN‐JAK/STAT axis of vertebrates has been proposed, wherein P. vannamei IRF could induce the activation of Vago4 gene and that Vago might function as an IFN‐like molecule in crustaceans. Vago using the unknown receptor induces STAT phosphorylation, which subsequently activates the transcription of antiviral genes 348,349 . The IRF‐Vago‐JAK/STAT axis can also trigger the expression of an interferon‐stimulated gene IFI6‐16, that thereafter mounts a caspase‐specific apoptosis response against viral infection in P. vannamei , suggesting an IRF‐JAK/STAT‐IFI6‐16 regulatory axis in shrimp 350 .…”

Section: Jak‐stat Signalling In Crustacean Innate Immunitymentioning

confidence: 99%

“…Proposed JAK‐STAT signalling cascade in crustacean innate immunity (conceptualized from Refs. 349,352,356). (a) IRF can transcribe Vago that could be sensed extracellularly by unknown receptors to phosphorylate the JAK kinases, which subsequently phosphorylate the dimerized STAT transcription factors to allow them to move inside the nucleus and bind to promoter elements of target AMPs.…”

Section: Jak‐stat Signalling In Crustacean Innate Immunitymentioning

confidence: 99%

“…Vago using the unknown receptor induces STAT phosphorylation, which subsequently activates the transcription of antiviral genes. 348,349 The IRF-Vago-JAK/STAT axis can also trigger the expression of an interferon-stimulated gene IFI6-16, that thereafter mounts a caspasespecific apoptosis response against viral infection in P. vannamei, suggesting an IRF-JAK/STAT-IFI6-16 regulatory axis in shrimp. 350 Dicer2 can also activate the promoter of Vagos, directing the activated STAT to translocate to the nucleus and confer immunity to S. paramamosain against MCRV.…”

Section: Down Syndrome Cell Adhesion Moleculementioning

confidence: 99%

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The role of pattern recognition receptors in crustacean innate immunity

Patnaik

Baliarsingh

Sarkar³

et al. 2023

Reviews in Aquaculture

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Crustacean species are among the most valued seafood with socioeconomic and ecological implications in the global fisheries sector. Microbial infections to the farming stock due to continued expansion and aquaculture puts global crustacean production at risk. Understanding and reviewing the complex innate immune system of crustaceans would be pivotal in formulating informed decisions for the control and management of epidemic diseases, thus making the global crustacean aquaculture industry sustainable. Under the purview of innate immunity in crustaceans, pattern recognition receptors (PRRs) represent the sensors capable of discriminating non‐self pathogenic modules and invoking the activation of immune responses. The immunity to infections can be manifested at cellular (via phagocytosis, apoptosis, nodulation and encapsulation) and humoral (effected by prophenoloxidase cascade, lectins, antimicrobial proteins) levels leading to the elimination of pathogens or subversion of the pathogenic implications. In this review, we discuss the participatory role of 12 types of PRRs identified from crustacean species with an exhaustive focus on structural and functional specificities in binding to pathogens and possible execution of the immune activity. Moreover, we have elaborated on the PRRs‐associated or possible signalling cascades (Toll‐NFκB, IMD‐NFκB and JAK‐STAT) in crustacean species that could bridge our understanding of the resistance or susceptibility of the host to varied pathogenic infections thus providing clues to the regulatory mechanisms involved in pathogenesis of infectious diseases and mechanisms of immunity.

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Section: Jak‐stat Signalling In Crustacean Innate Immunitymentioning

confidence: 99%

Section: Jak‐stat Signalling In Crustacean Innate Immunitymentioning

confidence: 99%