2014
DOI: 10.1002/jcp.24617
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The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease

Abstract: The monocytic leukemic zinc finger (MOZ) histone acetyltransferase (HAT) plays a role in acute myeloid leukemia (AML). It functions as a quaternary complex with the bromodomain PHD finger protein 1 (BRPF1), the human Esa1-associated factor 6 homolog (hEAF6), and the inhibitor of growth 5 (ING5). Each of these subunits contain chromatin reader domains that recognize specific post-translational modifications (PTMs) on histone tails, and this recognition directs the MOZ HAT complex to specific chromatin substrate… Show more

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Cited by 37 publications
(38 citation statements)
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“…MOZ has been identified as a fusion partner to various transcriptional regulators in several other genetic abnormalities [46,47]; these observations suggest that the MOZ-HAT tetraheterodimer and thereby the bromodomain-containing BRPF1 protein contributes to leukemic transformation also in these AML variants. One of these abnormalities is the inv(8) that causes a fusion between the MOZ-HAT and the TIF2 genes [48], and the encoded fusion protein forms a stable complex with the bromodomain-containing and histone-recognizing BRPF1 of the tetraheteromer.…”
Section: Other Genetic Abnormalities -Inv(8) and T(8;21)mentioning
confidence: 97%
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“…MOZ has been identified as a fusion partner to various transcriptional regulators in several other genetic abnormalities [46,47]; these observations suggest that the MOZ-HAT tetraheterodimer and thereby the bromodomain-containing BRPF1 protein contributes to leukemic transformation also in these AML variants. One of these abnormalities is the inv(8) that causes a fusion between the MOZ-HAT and the TIF2 genes [48], and the encoded fusion protein forms a stable complex with the bromodomain-containing and histone-recognizing BRPF1 of the tetraheteromer.…”
Section: Other Genetic Abnormalities -Inv(8) and T(8;21)mentioning
confidence: 97%
“…In this abnormality, MOZ forms a fusion gene with the p300 histone acetyl transferase; the MOZ acetyltransferase domain is intact, and aberrant acetyl transferase activity may thus be important for leukemogenesis also in this AML variant [46].…”
Section: The T(8;22) Translocationmentioning
confidence: 99%
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“…In melanoma, H3K4 demethylase JARID1B could be used as a biomarker to isolate a subpopulation of slowcycling melanoma cells [30]. MOZ (monocytic leukemic zinc finger) histone acetyltransferase in AML is associated with poor prognosis [31]. The non-coding RNAs, for instance, the microRNAs (miRNAs), also play crucial roles in epigenetic heterogeneity in CSCs.…”
Section: Sources Of Heterogeneity In Cancer Stem Cellsmentioning
confidence: 99%
“…BRPF1 is a component of the MOZ (monocytic leukemia zinc finger) histone acetyltransferase complex that stimulates this enzymatic activity on nucleosomal histone H3 and free histones H3 and H4, and promotes transcription (Ullah et al 2008). It may be that recognition of a histone trimethyllysine by BRPF1-PWWP contributes to the recruitment of the MOZ complex to the appropriate sites for acetylation (Carlson and Glass 2014).…”
Section: The Pwwp Domainmentioning
confidence: 99%