The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos

Kaneko, Tomomi; Miyagishima, Hiro; Hasegawa, Takanori; Mizutani-Koseki, Yoko; Isono, Kyoichi; Koseki, Haruhiko

doi:10.1016/s0378-1119(03)00800-x

Cited by 11 publications

(18 citation statements)

References 28 publications

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“…[42][43][44][45][46]. We have shown that, in addition to binding to caspase 8, zYaf2, like its mammalian counterpart (37,41), is capable of interacting with the mammalian Ring1A and Ring1B PcG proteins (data not shown). Accordingly, the apoptosis resulting from Yaf2 deficiency may relate in part to the Yaf2 interaction with PcG proteins and their involvement in these cellular processes.…”

Section: Discussionmentioning

confidence: 91%

Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis

Stanton

McReynolds

Evans

et al. 2006

Journal of Biological Chemistry

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Rybp (DEDAF) is a member of the Rybp/Yaf2 protein family and has been shown to encode pro-apoptotic functions and to be essential for mouse embryogenesis. The related Yaf2 protein has not been studied extensively at the cellular or organismal levels. Here we describe zebrafish yaf2 (zyaf2) and show that it is widely expressed during early embryogenesis, with subsequent enrichment of transcripts in the anterior head region. Depletion of zYaf2 during embryogenesis using specific morpholinos activates a wide-spread program of apoptosis and causes developmental arrest before the one somite stage. Partial depletion of Yaf2, achieved by injecting lower dosages of morpholino, circumvents the early arrest but leads to CNS degeneration associated with excessive apoptosis. These phenotypes can be rescued by co-injection of human YAF2 mRNA with the morpholinos or by treatment with a pan-caspase inhibitor or a caspase 8-specific inhibitor. Finally, the observed activation of caspase 8 in the morphants is in accord with the ability of Yaf2 to inhibit caspase 8-mediated apoptosis in cultured cells. Our findings implicate Yaf2 as a survival factor during early zebrafish development and organogenesis. This may suggest that Yaf2 and Rybp can encode opposing functions in the regulation of apoptosis.

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Section: Discussionmentioning

confidence: 91%

Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis

Stanton

McReynolds

Evans

et al. 2006

Journal of Biological Chemistry

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“…The human YAF2 was isolated as an interacting partner for YY1 [246]. Later, it was found that YAF2 also interacts with MYCN [247], MYC [248] and RING1/RNF2 [249]. YAF2 is paralog of RYBP [239] and together they constitute a functionally different cofactor family for YY1 and E4TF1/hGABP transcription factors [250].…”

Section: Core Members Of Ncprcsmentioning

confidence: 99%

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development

2018

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Originally two types of Polycomb Repressive Complexes (PRCs) were described, canonical PRC1 (cPRC1) and PRC2. Recently, a versatile set of complexes were identified and brought up several dilemmas in PRC mediated repression. These new class of complexes were named as non-canonical PRC1s (ncPRC1s). Both cPRC1s and ncPRC1s contain Ring finger protein (RING1, RNF2) and Polycomb group ring finger catalytic (PCGF) core, but in ncPRCs, RING and YY1 binding protein (RYBP), or YY1 associated factor 2 (YAF2), replaces the Chromobox (CBX) and Polyhomeotic (PHC) subunits found in cPRC1s. Additionally, ncPRC1 subunits can associate with versatile accessory proteins, which determine their functional specificity. Homozygous null mutations of the ncPRC members in mice are often lethal or cause infertility, which underlines their essential functions in mammalian development. In this review, we summarize the mouse knockout phenotypes of subunits of the six major ncPRCs. We highlight several aspects of their discovery from fly to mice and emerging role in target recognition, embryogenesis and cell-fate decision making. We gathered data from stem cell mediated in vitro differentiation assays and genetically engineered mouse models. Accumulating evidence suggests that ncPRC1s play profound role in mammalian embryogenesis by regulating gene expression during lineage specification of pluripotent stem cells.

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“…Alternatively, this suboptimal balance may exhaust the NPC pool, which obscures consequent differentiation events, since Rybp is a moonlighting protein and is involved in such diverse biological functions as ubiquitination [3], apoptosis [36], and transcriptional repression [4], and it may have multiple roles in regulating neural differentiation as well. It further complicates the situation that Yaf2 (the other member of the Rybp/Yaf2 gene family) may compensate for the lack of Rybp at certain extent [37,38].…”

Section: Discussionmentioning

confidence: 99%

Rybp is required for neural differentiation of mouse embryonic stem cells

Kovács

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The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos

Cited by 11 publications

References 28 publications

Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis

Yaf2 Inhibits Caspase 8-mediated Apoptosis and Regulates Cell Survival during Zebrafish Embryogenesis

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development

Rybp is required for neural differentiation of mouse embryonic stem cells

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