The Mouse Resources at the RIKEN BioResource Center

Yoshiki, Atsushi; Ike, Fumio; Mekada, Kazuyuki; Kitaura, Yasuyuki; Nakata, Hatsumi; Hiraiwa, Noriko; Mochida, Keiichi; Ijuin, Maiko; Kadota, Masayo; Murakami, Ayumi; Ogura, Atsuo; Abe, Kuniya; Moriwaki, Kazuo; Obata, Yuichi

doi:10.1538/expanim.58.85

Cited by 44 publications

(32 citation statements)

References 51 publications

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“…It was therefore argued that domesticated inbred mice are, in many ways, poorly suited to serve as models of 'normal' mice. Furthermore, it was suggested that genetically modifiable strains derived from wild house mice might serve as useful models, especially for experimental work in behavioural and brain sciences 30 . Thus, findings obtained from studies in wild-derived stocks might provide valuable opportunities to unravel the relationships between genotype and complex natural phenotypic traits that are reduced or even absent in domesticated stocks 10,14 , for example agonist behaviours in males and females, resistance to capture by humans (reviewed in ref.…”

Section: Discussionmentioning

confidence: 99%

Mapping ecologically relevant social behaviours by gene knockout in wild mice

et al. 2014

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The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, and adaptation to captivity, is of limited use for the study of fitness-driven behavioural responses that characterize the ancestral wild house mouse. Here, we demonstrate that the backcrossing of wild mice with knockout mutant laboratory mice retrieves behavioural traits exhibited exclusively by the wild house mouse, thereby unmasking gene functions inaccessible in the domesticated mutant model. Furthermore, we show that domestication had a much greater impact on females than on males, erasing many behavioural traits of the ancestral wild female. Hence, compared with laboratory mice, wild-derived mutant mice constitute an improved model system to gain insights into neuronal mechanisms underlying normal and pathological sexually dimorphic social behaviours.

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Section: Discussionmentioning

confidence: 99%

Mapping ecologically relevant social behaviours by gene knockout in wild mice

et al. 2014

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“…Thus the work of EMMA plays a crucial role in exploiting the tremendous potential benefits to human health presented by the current research in mammalian genetics (59). In Asia, AMMRA (Asian Mouse Mutagenesis Resources Association) was organized and shared their mice resources and information (60).…”

Section: Archiving and Bankingmentioning

confidence: 99%

Mouse phenogenomics, toolbox for functional annotation of human genome

Kim¹,

Shin²,

Seong³

2010

BMB Reports

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Mouse models are crucial for the functional annotation of human genome. Gene modification techniques including gene targeting and gene trap in mouse have provided powerful tools in the form of genetically engineered mice (GEM) for understanding the molecular pathogenesis of human diseases. Several international consortium and programs are under way to deliver mutations in every gene in mouse genome. The information from studying these GEM can be shared through international collaboration. However, there are many limitations in utility because not all human genes are knocked out in mouse and they are not yet phenotypically characterized by standardized ways which is required for sharing and evaluating data from GEM. The recent improvement in mouse genetics has now moved the bottleneck in mouse functional genomics from the production of GEM to the systematic mouse phenotype analysis of GEM. Enhanced, reproducible and comprehensive mouse phenotype analysis has thus emerged as a prerequisite for effectively engaging the phenotyping bottleneck. In this review, current information on systematic mouse phenotype analysis and an issue-oriented perspective will be provided. [BMB reports 2010; 43(2): 79-90]

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“…It always plays a key role in functional genomics [34]. Use of the BAC clone is not limited to the investigation of SNP.…”

Section: Bac Clonesmentioning

confidence: 99%

Genetic Materials at the Gene Engineering Division, RIKEN BioResource Center

et al. 2010

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Genetic materials are one of the most important and fundamental research resources for studying biological phenomena. Scientific need for genetic materials has been increasing and will never cease. Ever since it was established as RIKEN DNA Bank in 1987, the Gene Engineering Division of RIKEN BioResource Center (BRC) has been engaged in the collection, maintenance, storage, propagation, quality control, and distribution of genetic resources developed mainly by the Japanese research community. When RIKEN BRC was inaugurated in 2001, RIKEN DNA Bank was incorporated as one of its six Divisions, the Gene Engineering Division. The Gene Engineering Division was selected as a core facility for the genetic resources of mammalian and microbe origin by the National BioResource Project (NBRP) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan in 2002. With support from the scientific community, the Division now holds over 3 million clones of genetic materials for distribution. The genetic resources include cloned DNAs, gene libraries (e.g., cDNA and genomic DNA cloned into phage, cosmid, BAC, phosmid, and YAC), vectors, hosts, recombinant viruses, and ordered library sets derived from animal cells, including human and mouse cells, microorganisms, and viruses. Recently genetic materials produced by a few MEXT national research projects were transferred to the Gene Engineering Division for further dissemination. The Gene Engineering Division performs rigorous quality control of reproducibility, restriction enzyme mapping and nucleotide sequences of clones to ensure the reproducibility of in vivo and in vitro experiments. Users can easily access our genetic materials through the internet and obtain the DNA resources for a minimal fee. Not only the materials, but also information of features and technology related to the materials are provided via the web site of RIKEN BRC. Training courses are also given to transfer the technology for handling viral vectors. RIKEN BRC supports scientists around the world in the use of valuable genetic materials.

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The Mouse Resources at the RIKEN BioResource Center

Cited by 44 publications

References 51 publications

Mapping ecologically relevant social behaviours by gene knockout in wild mice

Mapping ecologically relevant social behaviours by gene knockout in wild mice

Mouse phenogenomics, toolbox for functional annotation of human genome

Genetic Materials at the Gene Engineering Division, RIKEN BioResource Center

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