The Mouse Olfactory System

Schröder, Hannsjörg; Moser, Natasha; Huggenberger, Stefan

doi:10.1007/978-3-030-19898-5_14

Cited by 5 publications

(3 citation statements)

References 22 publications

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“… 54 In most rodents, social information is primarily conveyed by chemosensory stimuli detected by the vomeronasal system, 113 , 114 , 115 whereas non-social olfactory stimuli are primarily detected through the main olfactory system. 116 , 117 We have previously shown that genetic disabling of VNO-mediated pheromone detection in wild-backcrossed TrpC2 −/− mice substantially impaired dyadic social interactions, specifically aggression, in both males and females. 16 Thus, it was reasonable to assume that obstruction of such a critical pathway for social communication 60 , 118 , 119 , 120 might severely impair the formation of dominance relationships.…”

Section: Discussionmentioning

confidence: 98%

Sex-dependent control of pheromones on social organization within groups of wild house mice

Zilkha¹,

Chuartzman²,

Sofer³

et al. 2023

Current Biology

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Section: Discussionmentioning

confidence: 98%

Sex-dependent control of pheromones on social organization within groups of wild house mice

Zilkha¹,

Chuartzman²,

Sofer³

et al. 2023

Current Biology

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“…The lamination and cytoarchitectural patterns observed in the meerkat MOB do not differ significantly from those found in other Carnivora [ 43 , 44 ], nor do they differ from the patterns described in species belonging to other mammalian orders, including Primates, such as the macaque [ 68 ]; Artiodactyla, such as the hippopotamus [ 69 ] or whale [ 70 ]; Proboscidea, such as the elephant [ 71 ]; or Rodentia, such as mice [ 72 ]. The MOB of the meerkat shows remarkable development of the GlL, containing an abundant number of PG cells, particularly in the deep zone; a broad MPL rich in abundant, and the neat organization of perfectly aligned mitral cells.…”

Section: Discussionmentioning

confidence: 98%

Neuroanatomical and Immunohistological Study of the Main and Accessory Olfactory Bulbs of the Meerkat (Suricata suricatta)

Torres

Ortiz‐Leal

Ferreiro³

et al. 2021

Animals

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We approached the study of the main (MOB) and accessory olfactory bulbs (AOB) of the meerkat (Suricata suricatta) aiming to fill important gaps in knowledge regarding the neuroanatomical basis of olfactory and pheromonal signal processing in this iconic species. Microdissection techniques were used to extract the olfactory bulbs. The samples were subjected to hematoxylin-eosin and Nissl stains, histochemical (Ulex europaeus agglutinin, Lycopersicon esculentum agglutinin) and immunohistochemical labelling (Gαo, Gαi2, calretinin, calbindin, olfactory marker protein, glial fibrillary acidic protein, microtubule-associated protein 2, SMI-32, growth-associated protein 43). Microscopically, the meerkat AOB lamination pattern is more defined than the dog’s, approaching that described in cats, with well-defined glomeruli and a wide mitral-plexiform layer, with scattered main cells and granular cells organized in clusters. The degree of lamination and development of the meerkat MOB suggests a macrosmatic mammalian species. Calcium-binding proteins allow for the discrimination of atypical glomerular subpopulations in the olfactory limbus between the MOB and AOB. Our observations support AOB functionality in the meerkat, indicating chemosensory specialization for the detection of pheromones, as identified by the characterization of the V1R vomeronasal receptor family and the apparent deterioration of the V2R receptor family.

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“…The OB is made up of five layers, which comprise the subependymal, combined mitral and granule cells, external plexiform, and glomerular layers [123,124]. The glomerular layer has an abundant expression of dopaminergic neurons [48,49].…”

Section: Discussionmentioning

confidence: 99%

Manganese and Vanadium Co-Exposure Induces Severe Neurotoxicity in the Olfactory System: Relevance to Metal-Induced Parkinsonism

Ngwa,

Bargues-Carot,

Jin

et al. 2024

IJMS

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Chronic environmental exposure to toxic heavy metals, which often occurs as a mixture through occupational and industrial sources, has been implicated in various neurological disorders, including Parkinsonism. Vanadium pentoxide (V2O5) typically presents along with manganese (Mn), especially in welding rods and high-capacity batteries, including electric vehicle batteries; however, the neurotoxic effects of vanadium (V) and Mn co-exposure are largely unknown. In this study, we investigated the neurotoxic impact of MnCl2, V2O5, and MnCl2-V2O5 co-exposure in an animal model. C57BL/6 mice were intranasally administered either de-ionized water (vehicle), MnCl2 (252 µg) alone, V2O5 (182 µg) alone, or a mixture of MnCl2 (252 µg) and V2O5 (182 µg) three times a week for up to one month. Following exposure, we performed behavioral, neurochemical, and histological studies. Our results revealed dramatic decreases in olfactory bulb (OB) weight and levels of tyrosine hydroxylase, dopamine, and 3,4-dihydroxyphenylacetic acid in the treatment groups compared to the control group, with the Mn/V co-treatment group producing the most significant changes. Interestingly, increased levels of α-synuclein expression were observed in the substantia nigra (SN) of treated animals. Additionally, treatment groups exhibited locomotor deficits and olfactory dysfunction, with the co-treatment group producing the most severe deficits. The treatment groups exhibited increased levels of the oxidative stress marker 4-hydroxynonenal in the striatum and SN, as well as the upregulation of the pro-apoptotic protein PKCδ and accumulation of glomerular astroglia in the OB. The co-exposure of animals to Mn/V resulted in higher levels of these metals compared to other treatment groups. Taken together, our results suggest that co-exposure to Mn/V can adversely affect the olfactory and nigral systems. These results highlight the possible role of environmental metal mixtures in the etiology of Parkinsonism.

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The Mouse Olfactory System

Cited by 5 publications

References 22 publications

Sex-dependent control of pheromones on social organization within groups of wild house mice

Sex-dependent control of pheromones on social organization within groups of wild house mice

Neuroanatomical and Immunohistological Study of the Main and Accessory Olfactory Bulbs of the Meerkat (Suricata suricatta)

Manganese and Vanadium Co-Exposure Induces Severe Neurotoxicity in the Olfactory System: Relevance to Metal-Induced Parkinsonism

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