The mouse olfactory peduncle. 3. Development of neurons, glia, and centrifugal afferents

Brunjes, Peter C.; Collins, Lindsay; Osterberg, Stephen K.; Phillips, Adriana M.

doi:10.3389/fnana.2014.00044

Cited by 8 publications

(11 citation statements)

References 46 publications

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“…4a). At this time the AON showed no signs of myelination (Brunjes et al, 2014). The amount of MBP labeling in the LOT increased across the period observed (F=47.78, p<0.001).…”

Section: Resultsmentioning

confidence: 93%

“…Three early ages (P7, 9, and 11) were chosen for a closer examination of the LOT because mature myelinating cells were already present by P10. Later ages (P11, 13, and 15) were chosen for AC analyses based on data presented above as well as previously reported results (Brunjes et al, 2014). Tissue was stained for expression of Olig2, PDGF, and MBP as these markers showed the largest changes across P10 to 30 and allow for distinguishing between all oligodendrocytes (Olig2+), oligodendrocyte precursor cells (PDGF+), and mature myelin sheaths (MBP+).…”

Section: Resultsmentioning

confidence: 99%

“…Axons from OB mitral cells project into the LOT very early during development, beginning around embryonic day (E)13 in mice and continuing until E16. By two weeks after birth collateral projections are well established (Blanchart et al, 2006; Brunjes et al, 2014; Walz et al, 2006). …”

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confidence: 99%

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Myelination of the developing lateral olfactory tract and anterior commissure

Collins

Hill

Brunjes

2018

J of Comparative Neurology

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Both the lateral olfactory tract (LOT) and anterior limb of the anterior commissure (AC) carry olfactory information. The LOT forms the projection from the olfactory bulb to the ipsilateral olfactory cortices, while the AC carries odor information across the midline to the contralateral olfactory cortex and bulb. The LOT and AC differ on a number of dimensions, including early development and functional onset. The present work, examining their myelination in mice, reveals additional important differences. For example, the LOT initiates myelination 3-4 days earlier than the AC, evidenced by both an earlier increase in myelin basic protein staining seen with immunohistochemistry and an earlier appearance of myelinated fibers using electron microscopy. While both exhibit a period of rapid myelination, it occurs 4-5 days earlier in the LOT than the AC. The tracts also respond differently to early sensory restriction. Unilateral naris occlusion from the day after birth to postnatal day 30 had no consistent effects on the AC but resulted in significantly thinner myelin sheaths relative to axon caliber in the LOT. Finally, the two tracts differ structurally (the LOT contains larger, more densely packed axons with significantly thicker myelin sheaths resulting in a conduction velocity that is more than twice as fast as the AC). The findings indicate that these two large, accessible tracts provide an important means for studying brain maturation due to basic differences in both the timing of their maturation and general organization.

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“…4a). At this time the AON showed no signs of myelination (Brunjes et al, 2014). The amount of MBP labeling in the LOT increased across the period observed (F=47.78, p<0.001).…”

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Myelination of the developing lateral olfactory tract and anterior commissure

Collins

Hill

Brunjes

2018

J of Comparative Neurology

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“…As newborn granule cells, which are the primary targets of these feedback projections are turned over throughout the organism’s life, including as a result of changes in experience (Lin et al, 2010), these maps may be further affected by changes in the circuit. In addition, this work does not explore how these circuits are formed over the course of development (Brunjes et al, 2014). These questions go beyond the scope of this work and may be the subject of future investigations.…”

Section: Discussionmentioning

confidence: 99%

Diverse Representations of Olfactory Information in Centrifugal Feedback Projections

Padmanabhan

Osakada

Tarabrina

et al. 2016

Journal of Neuroscience

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Although feedback or centrifugal projections from higher processing centers of the brain to peripheral regions have long been known to play essential functional roles, the anatomical organization of these connections remains largely unknown. Using a virus-based retrograde labeling strategy and 3D whole-brain reconstruction methods, we mapped the spatial organization of centrifugal projections from two olfactory cortical areas, the anterior olfactory nucleus (AON) and the piriform cortex, to the granule cell layer of the main olfactory bulb in the mouse. Both regions are major recipients of information from the bulb and are the largest sources of feedback to the bulb, collectively constituting circuits essential for olfactory coding and olfactory behavior. We found that, although ipsilateral inputs from the AON were uniformly distributed, feedback from the contralateral AON had a strong ventral bias. In addition, we observed that centrifugally projecting neurons were spatially clustered in the piriform cortex, in contrast to the distributed feedforward axonal inputs that these cells receive from the principal neurons of the bulb. Therefore, information carried from the bulb to higher processing structures by anatomically stereotypic projections is likely relayed back to the bulb by organizationally distinct feedback projections that may reflect different coding strategies and therefore different functional roles.

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“…The dense SOM innervation observed in both human and rodent OB peduncle supports the notion that external SOM sources compensate the imbalance between peptide and receptors levels in the OB. This would then suggest a role for SOM in centrifugal feedback mechanisms, as recently described for other neuromodulatory molecules (Brunjes et al, 2014;Guérin et al, 2009).…”

Section: Discussionmentioning

confidence: 93%