The mouse model of oxygen-induced retinopathy: A suitable animal model for angiogenesis research

Gole, Glen A.; Browning, J.; Elts, S. M.

doi:10.1007/bf02482605

Cited by 23 publications

(19 citation statements)

References 17 publications

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“…Our ability to demonstrate altered retinal function (with the exception of the a-wave) immediately after cessation of hyperoxic exposure would put less emphasis on the contribution of neovascularization to these manifestations, since this aggravated angiogenic process is known to be triggered after recovery in room air. 8,9,[47][48][49][50] Although in the present study we have not tried to quantify the level of neovascularization, our findings suggest that it may play a negligible role in the initial impairment of retinal function (at birth) compared with the devastating structural consequences (e.g., retinal detachment) that it could cause, should it fully manifest itself. If the above scenario also applies to the human counterpart, care will have to be taken when evaluating the functional consequences of hyperoxic exposure in human premature infants, despite the lack of significant evidence of underlying neovascularization.…”

Section: Discussionmentioning

confidence: 92%

Early Manifestations of Postnatal Hyperoxia on the Retinal Structure and Function of the Neonatal Rat

Dorfman

Dembinska

Chemtob³

et al. 2008

Invest. Ophthalmol. Vis. Sci.

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The findings confirm previous reports of reduced retinal vascular coverage that accompanies the earliest manifestation of postnatal hyperoxia in rats and suggest increased retinal susceptibility to hyperoxia within the first week of life. However, despite the fact that vasculature appears to repair itself, irreversible cytoarchitectural and functional changes occur, the consequences of which are documented immediately after the cessation of hyperoxia.

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Section: Discussionmentioning

confidence: 92%

Early Manifestations of Postnatal Hyperoxia on the Retinal Structure and Function of the Neonatal Rat

Dorfman

Dembinska

Chemtob³

et al. 2008

Invest. Ophthalmol. Vis. Sci.

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“…Although intense research has focused on the process of neovascularization, the mechanism regulating this process is not well understood because of the lack of a good animal model. 28,34,35 During HSV-1 infection, host proinflammatory immune cells are recruited to the site of infected tissues. In the case of the eye, these cells may lead to immunopathological disease by infiltrating the stroma and causing opacity and edema of this tissue.…”

Section: Discussionmentioning

confidence: 99%

A Viral Model for Corneal Scarring and Neovascularization Following Ocular Infection of Rabbits With a Herpes Simplex Virus Type 1 (HSV-1) Mutant

Barsam

Brick

Jones

et al. 2005

Cornea

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Rabbits infected with CJLAT developed corneal scarring and neovascularization similar to that of clinical ocular HSV-1 recurrent disease. Because this occurred well after the acute infection had resolved, the corneal scarring and neovascularization appeared to be recurrent disease. Thus, CJLAT ocular infection of rabbits may provide a good and reproducible animal model to study factors involved in corneal scarring and neovascularization from recurrent ocular HSV-1.

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“…Small animal models have been utilized to study the mechanisms of angiogenesis and collateral vessel growth (3,9,13,34). Insights gained from these models have played a role in the design of therapeutic strategies for clinical trials aimed at recovering vascular function in patients with peripheral artery disease (6,20,21,25,26,28,30,36,37).…”

Section: Discussionmentioning

confidence: 99%

Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury

Duvall¹,

Taylor²,

Weiss³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

211

218

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Transgenic mouse models are increasingly being used to investigate the functions of specific growth factors or matrix proteins to design therapeutic strategies for controlling blood vessel growth. However, the available methodologies for evaluating angiogenesis and arteriogenesis in these models are limited by animal size, user subjectivity, the power to visualize the three-dimensional vessel networks, or the capability to employ a vigorous quantitative analysis. In this study, we employed contrast-enhanced microcomputed tomography imaging to assess collateral development after induction of hindlimb ischemia in the mouse. The morphological parameters vessel volume, connectivity, number, thickness, thickness distribution, separation, and degree of anisotropy were evaluated in control and surgery limbs 0, 3, and 14 days postsurgery. Results indicate that the vascular volume of the surgically manipulated limb was reconstituted as early as 3 days after femoral artery excision through development of a series of highly connected, small caliber, closely spaced, and isotropically oriented collateral vessels. Parametric analyses were completed to assess the sensitivity of the calculated morphological parameters to variations in image binarization threshold and voxel size. Images taken at the 36-microm voxel size were found to be optimal for evaluating collateral vessel formation, whereas 8- to 16-microm voxel sizes were needed to resolve smaller vascular structures. This study demonstrates the utility of microcomputed tomography as a robust method for quantitative, three-dimensional analysis of blood vessel networks. Whereas these initial efforts focused on the mouse hindlimb ischemia model, the developed techniques may be applied to a variety of model systems to investigate mechanisms of angiogenesis and arteriogenesis.

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The mouse model of oxygen-induced retinopathy: A suitable animal model for angiogenesis research

Cited by 23 publications

References 17 publications

Early Manifestations of Postnatal Hyperoxia on the Retinal Structure and Function of the Neonatal Rat

Early Manifestations of Postnatal Hyperoxia on the Retinal Structure and Function of the Neonatal Rat

A Viral Model for Corneal Scarring and Neovascularization Following Ocular Infection of Rabbits With a Herpes Simplex Virus Type 1 (HSV-1) Mutant

Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury

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