The mouse epididymis: A site of strong and constitutive expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase (IDO)

Toné, Shigenobu; Britan, Aurore; Jrad, Aicha; Maffre, Violette; Drevet, Joël R.

doi:10.1016/j.ics.2007.07.035

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…In the mouse epididymis, IDO and the KYN pathway are constitutively activated [4]–[6]. In previous work we reported that epididymal IDO1 expression in the mouse is restricted to the caput region from segments 2 to 5 with a peak of expression in segments 3 to 4 [7].…”

Section: Introductionmentioning

confidence: 86%

Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment

et al. 2013

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The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1−/− model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1−/− animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.

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Section: Introductionmentioning

confidence: 86%

Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment

et al. 2013

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“…Within the caput, IDO1 expression starts posterior to segment 1 and peaks up at segments 3 and 4. It then goes down in segment 5 to undetectable levels further down the epididymis tubule epithelium [ 21 – 23 ]. At the cellular level, IDO1 expression was shown to concern preferentially principal and apical cells within the epididymal epithelium [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

The immunobiology of the mammalian epididymis: the black box is now open!

Guiton

Henry-Berger

Drevet

2013

Basic Clin. Androl.

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Spermatozoa represent an immunologic challenge for the mammalian males. They are produced long after the establishment of the immune library of the individual and harbor specific spermatic antigens that are found nowhere else in other organs, tissues and cells. Consequently, spermatozoa are somehow “foreign” to the male adaptive immune system. In order not to elicit autoimmune responses that would be detrimental for male fertility, spermatozoa should be either physically separated from the adaptive immune response and/or, the immune system challenged by spermatic antigens must be efficiently silenced. Within the mammalian male genital tract it becomes more and more obvious that a range of strategies are at stake to ensure that the immune-stranger spermatozoa do not constitute an immunological issue. In this review the focus will be on the immune status of the epididymis tubule, in which spermatozoa that have left the testes will mature for approximately 2 weeks and may be stored for prolonged period of time. How the epididymal immune environment compares to that of the testis and what are the immune regulatory processes at work in the epididymal compartment will only be briefly described. Instead, this review will focus on recent data that highlight epididymal immune regulatory actors that partly explain/illustrate the rather complicated, fragile but nevertheless robust immune environment of the epididymis.

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The mouse epididymis: A site of strong and constitutive expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase (IDO)

Cited by 2 publications

References 25 publications

Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment

Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment

The immunobiology of the mammalian epididymis: the black box is now open!

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