The mouse cortico-tectal projectome

Benavidez, Nora L.; Bienkowski, Michael S.; Khanjani, Neda; Bowman, Ian; Fayzullina, Marina; Garcia, Luis; Gao, Lei; Korobkova, Laura; Gou, Lin; Cotter, Kaelan; Becerra, Marlene; Aquino, Sarvia; Cao, Chunru; Foster, Nicholas N.; Song, Monica Y.; Zhang, Bin; Yamashita, Seita; Zhu, Muye; Lo, D.C.W.; Boesen, Tyler; Zingg, Brian; Santarelli, Anthony; Wickersham, Ian R.; Ascoli, Giorgio A.; Hintiryan, Houri; Dong, Hong‐Wei

doi:10.1101/2020.03.24.006775

Cited by 4 publications

(5 citation statements)

References 86 publications

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“…(2) projections to the reticular formation (e.g. MDRN) from cortico-medullar neurons are implicated in task-specific aspects of skilled motor programs 70 ; and (3) cortico-tectal projection to the SC is implicated in coordinating movements of eye, head, neck, and forelimbs during navigation and goal-oriented behaviors (such as escaping or appetite behavior) 71 . All L5 ET neurons and IT neurons generate projections to the striatum; and 'IT/PT balance'…”

Section: Discussionmentioning

confidence: 99%

Cellular Anatomy of the Mouse Primary Motor Cortex

Muñoz-Castañeda

Zingg

Matho

et al. 2020

Preprint

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An essential step toward understanding brain function is to establish a cellular-resolution structural framework upon which multi-scale and multi-modal information spanning molecules, cells, circuits and systems can be integrated and interpreted. Here, through a collaborative effort from the Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based description of one brain structure - the primary motor cortex upper limb area (MOp-ul) of the mouse. Applying state-of-the-art labeling, imaging, computational, and neuroinformatics tools, we delineated the MOp-ul within the Mouse Brain 3D Common Coordinate Framework (CCF). We defined over two dozen MOp-ul projection neuron (PN) types by their anterograde targets; the spatial distribution of their somata defines 11 cortical sublayers, a significant refinement of the classic notion of cortical laminar organization. We further combine multiple complementary tracing methods (classic tract tracing, cell type-based anterograde, retrograde, and transsynaptic viral tracing, high-throughput BARseq, and complete single cell reconstruction) to systematically chart cell type-based MOp input-output streams. As PNs link distant brain regions at synapses as well as host cellular gene expression, our construction of a PN type resolution MOp-ul wiring diagram will facilitate an integrated analysis of motor control circuitry across the molecular, cellular, and systems levels. This work further provides a roadmap towards a cellular resolution description of mammalian brain architecture.

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Section: Discussionmentioning

confidence: 99%

Cellular Anatomy of the Mouse Primary Motor Cortex

Muñoz-Castañeda

Zingg

Matho

et al. 2020

Preprint

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“…1A, Supplementary Video 1; 2 ). To understand the neural basis of this orienting action we focused on two brain regions: the retrosplenial cortex (RSP), which has been shown to encode the direction and angular velocity of the head, as well as the spatial locations of goals and rewards 10 ; and the superior colliculus (SC), which can generate orienting motor commands 11,12 as well as escape initiation 3,13 , and receives projections from the RSP 14,15 . By simultaneously recording single unit activity in these two regions while the animal explored the arena (Extended Data Fig.…”

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confidence: 99%

“…First, we characterised the anatomy of the RSP-SC projection 14,15 with cell type-specific monosynaptic retrograde rabies tracing 25 from vGluT2 + and vGAT + starter cells (Fig. 4E; N=6 each mice).…”

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confidence: 99%

A cortico-collicular circuit for accurate orientation to shelter during escape

Vale

Campagner²,

Ιορδανίδου³

et al. 2020

Preprint

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When faced with predatorial threats, escaping towards shelter is an adaptive action that offers long-term protection against the attacker. From crustaceans to mammals, animals rely on knowledge of safe locations in the environment to rapidly execute shelter-directed escape actions1–3. While previous work has identified neural mechanisms of instinctive escape4–9, it is not known how the escape circuit incorporates spatial information to execute rapid and accurate flights to safety. Here we show that mouse retrosplenial cortex (RSP) and superior colliculus (SC) form a monosynaptic circuit that continuously encodes the shelter direction. Inactivation of SC-projecting RSP neurons decreases SC shelter-direction tuning while preserving SC motor function. Moreover, specific inactivation of RSP input onto SC neurons disrupts orientation and subsequent escapes to shelter, but not orientation accuracy to a sensory cue. We conclude that the RSC-SC circuit supports an egocentric representation of shelter direction and is necessary for optimal shelter-directed escapes. This cortical-subcortical interface may be a general blueprint for increasing the sophistication and flexibility of instinctive behaviours.

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“…While our results support the idea that target acquisition is influenced by target selection via shared circuitry in the SC, they do not rule out a role for other brain regions in modulating target acquisition-related activity in the rostral SC. Indeed, the rostral SC integrates input from numerous brain regions (Benavidez et al, 2020;Doykos et al, 2020), many of which could contribute to processes related to target acquisition, including regulating movement speed and movement cessation. In particular, the cerebellar nuclei are thought to play a role in online motor control by modulating activity in movement-related circuitry, suggesting that their robust projections to the rostral SC contribute to target acquisition for SC-dependent orienting movements (Noorani and Carpenter, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Extensive sets of studies have focused on the role of the SC in both target selection (Sparks and Mays, 1980;Horwitz and Newsome, 1999;Glimcher, 2001;McPeek and Keller, 2002;Krauzlis et al, 2004;Felsen and Mainen, 2008;Duan et al, 2015;Basso and May, 2017) and acquisition (Guitton et al, 2003;Gandhi and Katnani, 2011;Marino et al, 2012;Smalianchuk et al, 2018), but it is unclear how these processes are related at the level of SC circuits. One possibility is that distinct sources of cortical and subcortical input to specific cell types along the rostrocaudal axis (Benavidez et al, 2020;Doykos et al, 2020) can mediate selection and acquisition via independent collicular pathways. Another underexamined possibility is that target selection and acquisition are intrinsically linked via SC circuitry.…”

Section: Introductionmentioning

confidence: 99%

Functional coupling between target selection and acquisition in the superior colliculus

Essig

Felsen

2021

Preprint

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To survive in unpredictable environments, animals must continuously evaluate their surroundings for behavioral targets, such as food and shelter, and direct their movements to acquire those targets. Although the ability to accurately select and acquire spatial targets depends on a shared network of brain regions, how these processes are linked by neural circuits remains unknown. The superior colliculus (SC) mediates the selection of spatial targets and remains active during orienting movements to acquire targets, which suggests the underexamined possibility that common SC circuits underie both selection and acquisition processes. Here, we test the hypothesis that SC functional circuitry couples target selection and acquisition using a default motor plan generated by selection-related neuronal activity. Single-unit recordings from intermediate and deep layer SC neurons in male mice performing a spatial choice task demonstrated that choice-predictive neurons, including optogenetically identified GABAergic SC neurons whose activity was causally related to target selection, exhibit increased activity during movement to the target. By strategically recording from both rostral and caudal SC neurons, we also revealed an overall caudal-to-rostral shift in activity as targets were acquired. Finally, we used an attractor model to examine how target selection activity in the SC could generate a rostral shift in activity during target acquisition using only intrinsic SC circuitry. Overall, our results suggest a functional coupling between SC circuits that underlie target selection and acquisition, elucidating a key mechanism for goal-directed behavior.

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The mouse cortico-tectal projectome

Cited by 4 publications

References 86 publications

Cellular Anatomy of the Mouse Primary Motor Cortex

Cellular Anatomy of the Mouse Primary Motor Cortex

A cortico-collicular circuit for accurate orientation to shelter during escape

Functional coupling between target selection and acquisition in the superior colliculus

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