The motility of the chicken embryo: Energetic cost and effects of hypoxia

Mortola, Jacopo P.; Louis, Alyssa; Simeonova, Marina; Velasquez, Paula A. Toro

doi:10.1016/j.resp.2013.05.030

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…Chick embryos display increased motor activity in response to hypoxia (Windle and Barcroft, ; Gräns and Altimiras, ; Mortola et al, ); this may serve as a distress signal to the hen to change incubation positions (Gräns and Altimiras, ). H/O neurons are known to stimulate locomotor activity in adult rats (Zheng et al, ) and in adult and neonatal birds (da Silva et al, ; Katayama et al, ).…”

Section: Discussionmentioning

confidence: 99%

Opposing effects of hypoxia on catecholaminergic locus coeruleus and hypocretin/orexin neurons in chick embryos

Landry

Hawkins

Wiebe

et al. 2014

Developmental Neurobiology

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Terrestrial vertebrate embryos face a risk of low oxygen availability (hypoxia) that is especially great during their transition to air-breathing. To better understand how fetal brains respond to hypoxia, we examined the effects of low oxygen availability on brain activity in late-stage chick embryos (day 18 out of a 21-day incubation period). Using cFos protein expression as a marker for neuronal activity, we focused on two specific, immunohistochemically identified cell groups known to play an important role in regulating adult brain states (sleep and waking): the noradrenergic neurons of the Locus Coeruleus (NA-LC), and the Hypocretin/Orexin (H/O) neurons of the hypothalamus. cFos expression was also examined in the Pallium (the avian analog of the cerebral cortex). In adult mammalian brains, cFos expression changes in a coordinated way in these areas. In chick embryos, oxygen deprivation simultaneously activated NA-LC while deactivating H/O-producing neurons; it also increased cFos expression in the Pallium. Activity in one pallial primary sensory area was significantly related to NA-LC activity. These data reveal that at least some of the same neural systems involved in brain-state control in adults may play a central role in orchestrating prenatal hypoxic responses, and that these circuits may show different patterns of coordination than seen in adults.

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Section: Discussionmentioning

confidence: 99%

Opposing effects of hypoxia on catecholaminergic locus coeruleus and hypocretin/orexin neurons in chick embryos

Landry

Hawkins

Wiebe

et al. 2014

Developmental Neurobiology

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“…The mechanisms of the effect of hypoxia on chick embryogenesis are being intensely studied; however, they remain unclear thus far. In addition, there are still limited data on how the chick embryonic motility changes under hypoxia [19,20]. Earlier, we showed that acute hypoxia (10% O 2 10 min) inhibited cyclic (or periodic) motility as estimated by its temporal parameters.…”

Section: Introductionmentioning

confidence: 90%

“…This effect was found to depend on embryonic age: the motility inhibition was weak on day 10 of embryogenesis (D10), but it was substantial on D14 [17]. At the same time, authors that estimated the overall motility of a chick embryo by measuring the pressure within the egg reported on variable and often insignificant effects of acute hypoxia (10% O 2 30 min) on body motion in the period D10-18, except for D16, when a significant decrease in the motility was observed [19]. In the same studies, a stronger hypoxia (5% O 2 ) consistently reduced body motion on D18.…”

Section: Introductionmentioning

confidence: 99%

Age-related Changes in the Response of Embryonic Motility to Acute Hypoxia During the Third Quarter of Chick Embryogenesis

Nechaeva¹,

Алексеева²

2017

TOOENIJ

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Environmental factors may affect the growth, size, phenotype, behavior, and other characteristics of avian embryos at different developmental stages; however, the roles of individual embryonic physiological systems in these effects remain largely unclear. Embryonic motility is an important component of the prenatal development observed almost throughout embryogenesis and may be a precursor of post-hatching motor behavior. The influences of the environment on the development of motor behavior during embryogenesis (notably the embryonic motility affected by hypoxia) remain poorly studied. Consequently, using the chick embryo, we investigated the effect of acute hypoxia (10% or 5% О 2 for 20 or 40 min) on embryonic cyclic motility at incubation days (D) 10, 12, 14, and 15 using in vivo video recording. Hypoxia inhibited motility; specifically, the average duration of activity and inactivity phases during hypoxic exposure were shortened and prolonged, respectively. Age-related changes in the responses to 10% and 5% O 2 differed. The time course of the motility response to acute hypoxia varied during the D10-15 period and demonstrates that the embryo was capable of recovering motility under hypoxia. The recovery was likely enhanced with age due to maturation of regulatory capacity.

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Effects of Hypoxia on the Contractile and Electrical Responses of Chick Embryo Skeletal Muscles in the Last Third of Embryogenesis

Кубасов

Nechaeva

Алексеева

2015

Neurosci Behav Physi

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The motility of the chicken embryo: Energetic cost and effects of hypoxia

Cited by 9 publications

References 34 publications

Opposing effects of hypoxia on catecholaminergic locus coeruleus and hypocretin/orexin neurons in chick embryos

Opposing effects of hypoxia on catecholaminergic locus coeruleus and hypocretin/orexin neurons in chick embryos

Age-related Changes in the Response of Embryonic Motility to Acute Hypoxia During the Third Quarter of Chick Embryogenesis

Effects of Hypoxia on the Contractile and Electrical Responses of Chick Embryo Skeletal Muscles in the Last Third of Embryogenesis

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