The most important stages of the mechanism of action in vivo of carcinogen diethylnitrosoamine and its effect on the synthesis of RNA, proteins, DNA, and deoxyribonucleotides

Dendrimer-conjugated podophyllotoxin suppresses DENA-induced HCC progression by modulation of inflammatory and fibrogenic factors

“…4 DENA acts by producing nitric oxide (NO), leading to hypoxic tissue condition, suppression of deoxyribonucleotide synthesis, and thus disturbing protein synthesis. 5 Aggressive treatment strategies for liver cancer are limited, and the development of drug resistance makes HCC treatment a great challenge. 1 Further, the prognosis of the disease remains poor due to the high rates of hepatic carcinoma relapse.…”