The Most Important Prognostic Factors for Gastric Cancer Patients: A Study Using Univariate and Multivariate Analyses

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

“…In our univariate survival analysis, the pT stage was the strongest prognostic factor but the accuracy was improved by separating mucosal and submucosal tumours from each other. The poorer survival for patients with submucosal invasion is also reported by others (Hermanek, 1986;Maruyama, 1987). Recently, in the supplement of TNM classification in 1993, this difference has been taken into account, and pT tumours are divided into Tla (mucosal) and Tlb (submucosal) tumours (Hermanek and Wittekind, 1995).…”

“…Among all prognostic factors in gastric cancer, the depth of tumour invasion and the presence of lymph node metastasis seem to be the most important factors in most studies (Maruyama, 1987;Yu et al, 1995). In our univariate survival analysis, the pT stage was the strongest prognostic factor but the accuracy was improved by separating mucosal and submucosal tumours from each other.…”

“…Clinical features including the size and location of the tumour have been used as prognostic factors in gastric cancer (Hermanek, 1986;Maruyama, 1987). The radicality of the operation as measured by tumour-free margins and the extent of lymphadenectomy have been shown to be of definitive prognostic value (Hermanek, 1986;Siewert et al, 1993), as has the age of the patient (Haugstvedt et al, 1993;Lisborg et al, 1994).…”

“…The radicality of the operation as measured by tumour-free margins and the extent of lymphadenectomy have been shown to be of definitive prognostic value (Hermanek, 1986;Siewert et al, 1993), as has the age of the patient (Haugstvedt et al, 1993;Lisborg et al, 1994). Thje most powerful prognostic factors in gastric cancer seem to be the depth of tumour invasion in the gastric wall, the status of local lymph nodes and the presence of distant metastases (Maruyama, 1987;Gabbert et al, 1991;Yu et al, 1995). This information is also included in the TNM classification which is the most widely used prognostic parameter in gastric cancer.…”

“…This information is also included in the TNM classification which is the most widely used prognostic parameter in gastric cancer. The size of the tumour and invasion to vascular and lymphatic system are related to the TNM classification and thus affect survival (Maruyama, 1987;Gabbert et al, 1991). Tumour differentiation (WHO grade) is also used as a prognostic factor (Lisborg et al, 1994;Yu et al, 1995).…”