The most important medicinal plants affecting sperm and testosterone production: a systematic review

Boroujeni, Shakiba Nasiri; Bossaghzadeh, Fatemeh; Malamiri, Farid Ansari; Esmaeili, Ali; Moudi, Emadoddin

doi:10.5935/1518-0557.20210108

Cited by 14 publications

(9 citation statements)

References 48 publications

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“…All studies (except one) have demonstrated the beneficial effects of these medicinal plants on male reproduction; however, more clinical trials are required to establish the maximum dose and treatment duration with herbal medicines, as well as to evaluate any possible adverse effects of this therapy, in order to develop novel strategies for the treatment of male infertility (Roozbeh et al 2021). The authors of the new systematic review of 2022 searched the databases Science Direct, PubMed, Scopus, PubMed Central, and Scientific between 2000 and 2020 using search queries (Boroujeni et al 2022). Based on the results of 35 studies, it was determined that such plants as Apium graveolens, Cinnamomum camphora, Cornus mas, Satureja khuzestanica, Withania somnifera, Fumaria parviflora, Zingiber officinale, Cinnamomum zeylanicum and Phoenix dactylifera had a positive effect on reproduction, and demonstrated antioxidant effects and a low frequency of side effects (Boroujeni et al 2022).…”

Section: Resultsmentioning

confidence: 99%

“…The authors of the new systematic review of 2022 searched the databases Science Direct, PubMed, Scopus, PubMed Central, and Scientific between 2000 and 2020 using search queries (Boroujeni et al 2022). Based on the results of 35 studies, it was determined that such plants as Apium graveolens, Cinnamomum camphora, Cornus mas, Satureja khuzestanica, Withania somnifera, Fumaria parviflora, Zingiber officinale, Cinnamomum zeylanicum and Phoenix dactylifera had a positive effect on reproduction, and demonstrated antioxidant effects and a low frequency of side effects (Boroujeni et al 2022). Many nutraceuticals can stimulate steroidogenesis in men, according to Santos et al (2022).…”

Section: Resultsmentioning

confidence: 99%

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Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Bratchikov,

Tyuzikov,

Grekov

2023

RRP

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Introduction: Male infertility is an topical medical and social problem of modern reproductive medicine. Its pharmacotherapy is often empirical in nature, and the most popular method remains the use of various herbal substances (phytotherapy), the effectiveness of which remains still understudied in the framework of evidence-based medicine. Materials and Methods: The results of research, thematic, systematic and Cochrane reviews and meta-analyses were searched in Medline/PubMed medical databases over the past 5 years using the search queries "plants male infertility", "plants sperm", "phytotherapy male infertility", "phytomedicinal therapeutics male infertility", "systematic review", "meta-analysis", and "review". Results: The vast majority of herbal substances offered for the treatment of male infertility demonstrate insufficient or contradictory evidence base for their clinical effectiveness, although some of them can be very useful pharmacotherapeutic options in the combined therapy of male infertility. Conclusion: Not all plant substances with a "reproductive effect" positioned in them actually have proven reproductive effects in studies in humans, therefore, the choice of phytotherapeutic agents in the treatment of idiopathic male infertility should be currently approached extremely carefully, especially in cases when we choose phytotherapy as an option for empirical monotherapy of male reproductive disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Bratchikov,

Tyuzikov,

Grekov

2023

RRP

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“…As mentioned earlier, acting on the HPG axis and thus affecting sex hormone balance appears to be an essential modulation. A plausible mechanism may be that Ashwagandha acts on GABA receptors in the hypothalamus, facilitating the expression of GnRH [49], which in turn stimulates the pituitary gland to secrete LH and FSH [50,51].…”

Section: Ashwagandha's Impact On the Reproductive Systemmentioning

confidence: 99%

Can Ashwagandha Benefit the Endocrine System?—A Review

Wiciński,

Fajkiel-Madajczyk,

Kurant

et al. 2023

IJMS

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Withania somnifera, also known as Ashwagandha, has been used in traditional medicine for thousands of years. Due to the wide range of its activities, there has been interest in its possible beneficial effects on the human body. It is proved that, among others, Ashwagandha has anti-stress, anti-inflammatory, antimicrobial, anti-cancer, anti-diabetic, anti-obesity, cardioprotective, and hypolipidemic properties. Particularly interesting are its properties reported in the field of psychiatry and neurology: in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, depression, bipolar disorder, insomnia, anxiety disorders and many others. The aim of this review is to find and summarize the effect that Ashwagandha root extract has on the endocrine system and hormones. The multitude of active substances and the wide hormonal problems faced by modern society sparked our interest in the topic of Ashwagandha’s impact on this system. In this work, we also attempted to draw conclusions as to whether W. somnifera can help normalize the functions of the human endocrine system in the future. The search mainly included research published in the years 2010–2023. The results of the research show that Ashwagandha can have a positive effect on the functioning of the endocrine system, including improving the secretory function of the thyroid gland, normalizing adrenal activity, and multidirectional improvement on functioning of the reproductive system. The main mechanism of action in the latter appears to be based on the hypothalamus–pituitary–adrenal (HPA) axis, as a decrease in cortisol levels and an increase in hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in men were found, which results in stress level reduction and improvement in fertility. In turn, other studies prove that active substances from W. somnifera, acting on the body, cause an increase in the secretion of triiodothyronine (T3) and thyroxine (T4) by the thyroid gland and a subsequent decrease in the level of thyroid-stimulating hormone (TSH) in accordance with the hypothalamus–pituitary–thyroid (HPT) axis. In light of these findings, it is clear that Ashwagandha holds significant promise as a natural remedy for various health concerns, especially those related to the endocrine system. Future research may provide new insights into its mechanisms of action and expand its applications in both traditional and modern medicine. The safety and toxicity of Ashwagandha also remain important issues, which may affect its potential use in specific patient groups.

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“…Recently, use of traditional medicines from medicinal plants has increased in treating male infertility. Many studies show evidence of the effect of medicinal herbs on the testicular tissue, epididymis, spermatogenesis, steroidogenesis, testosterone production, erection function, ejaculation, and libido [ 26 , 27 ]. Therefore, the aim of this study was to investigate the effect of Curculigo orchioides extract on testicular histopathology alteration and blood testosterone levels in heat stress-induced male mice.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model

Bui-Le

Quảng

Hoang-Viet

et al. 2023

CIMB

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Curculigo orchioides Gaertn. is a precious herb used in traditional medicine systems in Asian countries for various health benefits. This study investigated the potential protective effects of C. orchioides extract on reproductive health under heat stress conditions in male mice. Forty-eight mice were divided into eight groups, control condition (C group), C. orchioides extract at the dosages of 100, 200, and 400 mg/kg/day (C100, C200, C400 group), 40 °C heat exposure (H group), and combined 40 °C heat exposure and C. orchioides extract at the dosages of 100, 200, and 400 mg/kg/day (HC100, HC200, HC400 group). The result shows that the mice that received only C. orchioides extract without heat stress do not have a significant change in histological structure and testosterone level. The histological analysis of testicular tissue showed that heat stress conditions reduced reproductive function and inhibited the spermatogenesis of male mice. The C. orchioides rhizome extract treatment attenuated the heat stress-induced spermatogenesis complications in the murine model. Mice in the heat-stress group treated with C. orchioides extract had increased spermatogenic cells and spermatozoa compared with mice exposed to heat without C. orchioides treatment. Moreover, the aqueous extract of C. orchioides rhizome enhanced the serum total testosterone levels in heat-exposed mice. In conclusion, the study findings validate that C. orchioides is effective against heat stress-induced spermatogenesis complications in the murine model.

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The most important medicinal plants affecting sperm and testosterone production: a systematic review

Cited by 14 publications

References 48 publications

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Can Ashwagandha Benefit the Endocrine System?—A Review

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model

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