The most important inferences from the Ekaterinburg nanotoxicology team’s animal experiments assessing adverse health effects of metallic and metal oxide nanoparticles

Sutunkova, Marina P.; Privalova, Larisa I.; Minigalieva, Ilzira A.; Gurvich, Vladimir B.; Panov, Vladimir G.; Katsnelson, Boris A.

doi:10.1016/j.toxrep.2018.03.008

Cited by 29 publications

(21 citation statements)

References 99 publications

(123 reference statements)

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“…Previously, we demonstrated that the deposition of nanoparticles in the lungs as a result of intratracheal administration [11][12][13][14] or inhalation exposure [6][7][8] caused a response in the lower airways that was essentially similar to but a lot more intensive than the one provoked by similar exposures to low-soluble highly cytotoxic micrometer particles, such as, for instance, quartz dust [15,16]. This response manifests itself as an increase in the cellularity of the bronchoalveolar lavage fluid (BALF), mainly at the expense of neutrophil leukocytes.…”

Section: Resultsmentioning

confidence: 99%

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development).

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Section: Resultsmentioning

confidence: 99%

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

Self Cite

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“…Among other causes, even high temperature processes, such as welding, can generate nanoparticles. The results of many in vivo and in vitro researches suggest that nickel and nickel oxide nanoparticles are responsible for lung toxicity, inflammation, oxidative stress and apoptosis [43][44][45].…”

Section: Nickel Toxicity and Carcinogenicitymentioning

confidence: 99%

Nickel: Human Health and Environmental Toxicology

Genchi

Carocci

Lauria

et al. 2020

IJERPH

915

383

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Nickel is a transition element extensively distributed in the environment, air, water, and soil. It may derive from natural sources and anthropogenic activity. Although nickel is ubiquitous in the environment, its functional role as a trace element for animals and human beings has not been yet recognized. Environmental pollution from nickel may be due to industry, the use of liquid and solid fuels, as well as municipal and industrial waste. Nickel contact can cause a variety of side effects on human health, such as allergy, cardiovascular and kidney diseases, lung fibrosis, lung and nasal cancer. Although the molecular mechanisms of nickel-induced toxicity are not yet clear, mitochondrial dysfunctions and oxidative stress are thought to have a primary and crucial role in the toxicity of this metal. Recently, researchers, trying to characterize the capability of nickel to induce cancer, have found out that epigenetic alterations induced by nickel exposure can perturb the genome. The purpose of this review is to describe the chemical features of nickel in human beings and the mechanisms of its toxicity. Furthermore, the attention is focused on strategies to remove nickel from the environment, such as phytoremediation and phytomining.

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“…Additionally, hot processes such as welding can generate exposures in the nano size range. In vitro and in vivo studies suggest that these nickel nanoparticles are primarily associated with lung toxicity, inflammation, oxidative stress, and apoptosis, e.g., [250][251][252][253][254][255][256][257]. Recent inhalation studies indicate possible differences in toxicokinetics between NiO nanoparticle and larger micron particles [48,252,253,256,257].…”

Section: Nanoparticlesmentioning

confidence: 99%

Concise Review of Nickel Human Health Toxicology and Ecotoxicology

Buxton¹,

Garman²,

Heim³

et al. 2019

Inorganics

158

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Nickel (Ni) metal and Ni compounds are widely used in applications like stainless steel, alloys, and batteries. Nickel is a naturally occurring element in water, soil, air, and living organisms, and is essential to microorganisms and plants. Thus, human and environmental nickel exposures are ubiquitous. Production and use of nickel and its compounds can, however, result in additional exposures to humans and the environment. Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. These effects have thresholds, with indirect genotoxic and epigenetic events underlying the threshold mode of action for nickel carcinogenicity. Differences in human toxicity potencies/potentials of different nickel chemical forms are correlated with the bioavailability of the Ni2+ ion at target sites. Likewise, Ni2+ has been demonstrated to be the toxic chemical species in the environment, and models have been developed that account for the influence of abiotic factors on the bioavailability and toxicity of Ni2+ in different habitats. Emerging issues regarding the toxicity of nickel nanoforms and metal mixtures are briefly discussed. This review is unique in its covering of both human and environmental nickel toxicity data.

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The most important inferences from the Ekaterinburg nanotoxicology team’s animal experiments assessing adverse health effects of metallic and metal oxide nanoparticles

Cited by 29 publications

References 99 publications

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Nickel: Human Health and Environmental Toxicology

Concise Review of Nickel Human Health Toxicology and Ecotoxicology

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