“…Loss of TP53 gene is frequently due to rearrangements involved in chromosome region 17p10, 17p12 (Fink et al, 2006;Mayr et al, 2006). Some translocations affecting this region have been described t(17;21)(p11;q11), dic(15;17)(p11;p11), dic(17;18)(p11;p11), dic(4;17)(p11;p11) ( Döhner et al, 1995;Callet-Bauchu et al, 1996;Chapiro et al, 2008;Woyach et al, 2010). In addition, patients with translocations have been reported to have higher CD38 expression, advanced disease and significantly inferior overall survival than those without translocations (Mayr et al, 2006;Cavazzini et al, 2008).…”