The Most Common Vitamin D Receptor Polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) in Children with Dental Caries: A Systematic Review and Meta-Analysis

Sadeghi, Masoud; Golshah, Amin; Godiny, Mostafa; Sharifi, Roohollah; Khavid, Atefeh; Nikkerdar, Nafiseh; Tadakamadla, Jyothi

doi:10.3390/children8040302

Cited by 13 publications

(17 citation statements)

References 50 publications

(26 reference statements)

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“…The results of meta-analysis of allelic, recessive, dominant, and overdominant models at rs739837, rs2228570, and rs7975232 revealed no signi cant differences in genotype distributions between the caries and caries-free groups, consistent with the ndings of Sadeghi et al [43] ,…”

Section: Discussionsupporting

confidence: 88%

“…Sadeghi et al [43] named genotypes at this locus based on restriction of endonuclease digestion sites. After one-to-one comparison, the results of this study were consistent with those of Sadeghi et al [43] . The reason why rs10735810 is associated with susceptibility to caries may be related to the interaction of its cotranscription factors and its location in the gene structure [46] ; rs10735810 is located near the 5'untranslated region of the VDR gene, within the DNA binding domain [47][48][49][50] , and the polymorphism changes the rst potential start codon of the VDR gene, from ATG to ACG, resulting in a VDR protein truncated by three amino acids, which is more effective in transactivation of vitamin D target genes [51] .…”

Section: Discussionmentioning

confidence: 99%

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Association of Vitamin D Receptor Gene Polymorphisms with Caries Risk: A Systematic Review and Meta-analysis

Qin,

Wang,

Wang

et al. 2024

Preprint

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Background In this study, we aimed to evaluate the association of Vitamin D receptor (VDR) gene polymorphisms with caries risk in children (< 18 years).Methods The electronic databases PubMed, Cochrane, EMBASE, Web of Science, CNKI, Cqvip, and Wanfang were searched for observational studies on the relationship between VDR polymorphisms and caries, including cohort, case-control, and cross-sectional studies. Quality assessment of selected studies was conducted using the Newcastle Ottawa scale. Odds ratios (OR) with 95% confidence intervals (CI) values for associations of individual VDR polymorphisms with dental caries were calculated based on four genetic models: allelic, recessive, dominant, and overdominant. Of 79 studies considered, 10 (nine case-control and one cross-sectional) were selected for analysis; the studies involved seven VDR single nucleotide polymorphisms: rs731236, rs739837, rs10735810, rs2228570, rs7975232, rs1544410, and rs11568820.Results Alleles C and T of rs10735810 were significantly differently distributed in the caries and caries-free groups (OR = 1.33, 95% CI: 1.30–2.30, P = 0.03), with CC + CT genotypes at this locus associated with greater risk of developing caries than the TT genotype (OR = 1.87, 95%CI: 1.15–3.04, P = 0.01). Further, TT + CC genotype at rs731236 was associated with a 1.33-fold higher risk of caries development than the TC genotype (OR = 1.33, 95%CI:1.06–1.67,P = 0.02). On subgroup analysis, the association between rs731236 and caries risk was affected by dentition type, ethnicity, and genotyping method (permanent dentition: OR = 1.48, 95%CI: 1.07–2.03, P = 0.02; Asian: OR = 1.38, 95%CI: 1.02–1.87, P = 0.03; quantitative PCR test: OR = 1.52, 95% CI: 1.10–2.10, P = 0.01). Genotype distributions at rs1544410, rs739837, rs2228570, and rs7975232 did not differ significantly between the caries and caries-free groups.Conclusions Caries risk was associated with rs731236 and rs10735810 genotypes, and rs731236 may be a risk factor for permanent teeth caries among Asian people.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D Receptor Gene Polymorphisms with Caries Risk: A Systematic Review and Meta-analysis

Qin,

Wang,

Wang

et al. 2024

Preprint

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“…disorders (Yildiz et al, 2021), and the Bb (AG) and bb (GG) genotypes are associated with caries risk in children (Kong et al, 2017;Sadeghi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

et al. 2022

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ObjectiveTo investigate the relationship between the polymorphisms rs1544410 (BsmI), rs2228570 (FokI) and rs731236 (TaqI) and DNA methylation status in the VDR gene (vitamin D receptor) with oral mucositis (OM) in oncopaediatric patients treated with methotrexate (MTX®).MethodsThe population comprised healthy patients with haematological malignancies aged between 5 and 19 years. An evaluation of oral conditions was performed using the Oral Assessment Guide. Demographic, clinical, biochemical and haematological data were obtained from medical records. Genomic DNA from oral mucosal cells was used for the analysis of polymorphisms (n = 102) (PCR‐restriction fragment length polymorphism) and DNA methylation (n = 81) (methylation‐specific PCR).ResultsMales predominated (57.8%), and the mean age was 10.3 years (±4.7). OM affected 84.3% of patients, of which 53.1% developed severe oral mucositis (SOM). Patients with OM had lower platelet and leukocyte counts (p < 0.05). The G allele of rs1544410 (p = 0.040) and the CT genotype of rs2228570 polymorphisms were associated with SOM (p = 0.038). A partially methylated status in the VDR promoter was found in all patients.ConclusionOM is associated with lower leukocyte and platelet counts. SOM is associated with the rs1544410 and rs2228570 polymorphisms. The methylation status of the VDR is not associated with inflammation or exposure to MTX®.

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“…As a result, optimum vitamin D3 levels in children are required as a secondary preventive intervention for dental cavities in the permanent dentition [ 26 ]. Another study concluded that among the vitamin D3 receptor polymorphisms studied, a relation was found between the FokI polymorphism (rs10735810) and the risk of dental caries, with the protective effect of the f allele and ff genotype [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study

Al-Jubori¹,

AL-Murad²,

Al-Mashhadane³

2022

Cureus

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Aim Vitamin D3 plays an important role in affecting the overall remineralization process of the dentition. The use of supplements help to keep the levels at optimum and thus reduce the chances of treating very early lesion of caries. Hence the aim was to investigate the indirect effects of oral vitamin D3 on microhardness and elemental weight percentage of Calcium (Ca) and Phosphorous (P) in enamel surface with an artificially initiated carious lesion. Methods The 120 extracted premolars were randomly divided into five groups according to salivary immersion. Each group had a total of twenty-four participants, with the following characteristics: control +ve: sound enamel; control -ve: only subjected to pH cycle; A: pH cycle and immersion in control saliva; B: pH cycle and saliva collected after three weeks; and C: pH cycle and saliva collected after six weeks. The unstimulated saliva was collected from (40) adult volunteers receiving vitamin D3 1000IU gel capsules daily for six weeks. Before each vitamin D3 intake, 10 mL of unstimulated control saliva was collected from each participant. Then other 10 ml. were collected after three and six weeks of vitamin D receiving periods. Saliva immersion time (12 hours). Enamel surface was assessed by Vicker’s Microhardness machine and (X-ray fluorescence - XRF) spectrometer. Results For all specimens, there was a significant decrease in both (Ca and P weight %) after demineralization and then they significantly increased after receiving vitamin D3. The microhardness and elemental analysis provide confirmed results that were represented as a statistically significant difference at (P≤ 0.05) between groups that received vitamin D3 and those without vitamin D3 dosage. Conclusions Oral vitamin D3 has a significant potential in motivating remineralization of early lesions on the enamel surfaces representing improved surface microhardness and minerals content (Ca and P weight %) of demineralized tooth surfaces.

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The Most Common Vitamin D Receptor Polymorphisms (ApaI,FokI, TaqI, BsmI, and BglI) in Children with Dental Caries: A Systematic Review and Meta-Analysis

Cited by 13 publications

References 50 publications

Association of Vitamin D Receptor Gene Polymorphisms with Caries Risk: A Systematic Review and Meta-analysis

Association of Vitamin D Receptor Gene Polymorphisms with Caries Risk: A Systematic Review and Meta-analysis

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study

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