This paper updates the mortality cost of expenditures, which has relevance to a broad range of policies, including regulations, wars, and COVID-19 restrictions. Because changes in income lead to changes in mortality risk, health investments costing more per life saved than a threshold cost-per-life-saved cutoff level are expected to increase mortality risk. This article discusses the mechanisms driving this relationship and provides recent empirical support. The 2019 cost-per-life-saved cutoff level at which expenditures increase mortality risk has a lower bound of $83.