The mortality and years of life lost for community-acquired pneumonia before and during COVID-19 pandemic in China

Fan, Guohui; Zhou, Yuchang; Zhou, Fei; Yu, Zhongguang; Gu, Xiaoying; Zhang, Xueyang; Liu, Zhengping; Zhou, Maigeng; Cao, Bin

doi:10.1016/j.lanwpc.2023.100968

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Among hospitalized adults, CAP is associated with a substantial mortality burden of over 100,000 in-hospital deaths per year ( 3 , 5 ). The combination of CAP and influenza remains among the top 10 leading causes of death in the US, ranking 9th in 2020, while the mortality rate of CAP ranks the highest among infectious diseases ( 5 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

The relationship between neighborhood economic deprivation and community-acquired pneumonia related admissions in Maryland

Akinyemi,

Fasokun,

Odusanya

et al. 2024

Front. Public Health

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IntroductionCommunity-acquired pneumonia (CAP) is a major health concern in the United States (US), with its incidence, severity, and outcomes influenced by social determinants of health, including socioeconomic status. The impact of neighborhood socioeconomic status, as measured by the Distressed Communities Index (DCI), on CAP-related admissions remains understudied in the literature.ObjectiveTo determine the independent association between DCI and CAP-related admissions in Maryland.MethodsWe conducted a retrospective study using the Maryland State Inpatient Database (SID) to collate data on CAP-related admissions from January 2018 to December 2020. The study included adults aged 18–85 years. We explored the independent association between community-level economic deprivation based on DCI quintiles and CAP-related admissions, adjusting for significant covariates.ResultsIn the study period, 61,467 cases of CAP-related admissions were identified. The patients were predominantly White (49.7%) and female (52.4%), with 48.6% being over 65 years old. A substantive association was found between the DCI and CAP-related admissions. Compared to prosperous neighborhoods, patients living in economically deprived communities had 43% increased odds of CAP-related admissions.ConclusionResidents of the poorest neighborhoods in Maryland have the highest risk of CAP-related admissions, emphasizing the need to develop effective public health strategies beneficial to the at-risk patient population.

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Section: Introductionmentioning

confidence: 99%

The relationship between neighborhood economic deprivation and community-acquired pneumonia related admissions in Maryland

Akinyemi,

Fasokun,

Odusanya

et al. 2024

Front. Public Health

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Distribution characteristics of human herpes viruses in the lower respiratory tract and their impact on 30-day mortality in community-acquired pneumonia patients

Ding,

Liu,

et al. 2024

Front. Cell. Infect. Microbiol.

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Human herpes viruses (HHVs) are commonly detected in community-acquired pneumonia (CAP) patients, particularly those with complex complications, attracting increased attention from clinical practitioners. However, the significance of detecting HHVs in bronchoalveolar lavage fluid (BALF) with CAP patients is still unclear. This study retrospectively analyzed BALF samples from 64 CAP patients at the Kunming Third People’s Hospital between August 2021 and December 2023. Metagenomic next generation sequencing (mNGS) was conducted on BALF samples during CAP onset. Multivariate Cox regression models were used to identify independent risk factors for 30-day all-cause mortality in CAP. HHVs were found in 84.4% of CAP patients, which were the most common pathogens (45.1%), followed by bacteria (30.2%) and fungi (11.5%). Bacterial-viral co-infections were most common, occurring in 39 patients. Notably, there was no significant difference in HHV presence between severe and non-severe CAP patients (EBV: P = 0.431, CMV: P = 0.825), except for HHV-7 (P = 0.025). In addition, there was no significant difference in the 30-day mortality between HHV positive and HHV negative groups (P = 0.470), as well as between the HHV-7 positive and HHV-7 negative groups (P = 0.910). However, neither HHVs nor HHV-7 was independent risk factors for 30-day mortality in CAP patients (HHVs: HR 1.171, P = 0.888; HHV-7: HR 1.947, P = 0.382). In summary, among the prevalent presence of multiple HHVs, EBV and CMV were the most prevalent in CAP patients. Patients with sCAP were more susceptible to HHV-7 than those with non-sCAP. These results provide valuable insights for clinicians in guiding appropriate interventions for CAP treatment.

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The mortality and years of life lost for community-acquired pneumonia before and during COVID-19 pandemic in China

Cited by 2 publications

References 33 publications

The relationship between neighborhood economic deprivation and community-acquired pneumonia related admissions in Maryland

The relationship between neighborhood economic deprivation and community-acquired pneumonia related admissions in Maryland

Distribution characteristics of human herpes viruses in the lower respiratory tract and their impact on 30-day mortality in community-acquired pneumonia patients

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