The morphology of mucus in mammalian pulmonary airways

As, Anderson; Webster, Ian

doi:10.1016/0013-9351(74)90071-1

Cited by 30 publications

(11 citation statements)

References 12 publications

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“…In part, this uncertainty reflects the fact that it is not known whether mucus is inherently lumpy or smooth in vivo in health or disease. 29,30 If mucus is inherently lumpy in vivo, plug selection may only sample one component of mucus. In this context, it was striking that the sputum weight of IS samples was much larger (~ 300% greater) than the SS samples, whereas the effects on plug dilution (percent solids and total mucin) was much smaller (~ 13% and 11%, respectively).…”

Section: Discussionmentioning

confidence: 99%

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum

Henderson

Anderson

Ceppe

et al. 2018

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Mucus hydration is important in mucus clearance and lung health. This study sought to test the relative utility of spontaneous sputum (SS) vs. the reasonably non-invasive induced sputum (IS) samples for measurement of mucus hydration. SS and IS samples were collected over a two-day study interval. Sputum was induced with escalating inhaled nebulized 3-5% hypertonic saline. Viscous portions of the samples ("plugs") were utilized for percent solids and total mucin analyses. Cytokines, nucleotides/nucleosides, and cell differentials were measured in plugs diluted into 0.1% Sputolysin. Overall, 61.5% of chronic bronchitis (CB) subjects produced a SS sample and 95.2% an IS sample. Total expectorate sample weights were less for the SS (0.94 ± 0.98 g) than the IS (2.67 ± 2.33 g) samples. Percent solids for the SS samples (3.56% ± 1.95; n=162) were significantly greater than the IS samples (3.08% ± 1.81; n=121), p=0.133. Total mucin

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Section: Discussionmentioning

confidence: 99%

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum

Henderson

Anderson

Ceppe

et al. 2018

COPD: Journal of Chronic Obstructive Pulmonary Disease

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“…Moreover, an individual microdisk could exhibit both fast and slow transport rates at different time points during a study. The heterogeneous rates of MCT suggest that, even in healthy airways, a homogeneous blanket of mucus might not cover the airways (15,(19)(20)(21)(22). This heterogeneity could be related to multiple factors, including variability in submucosal gland secretions, unevenness in mucus layer thickness, or regional differences in mucus biophysical properties and cell types/ submucosal glands.…”

Section: Mct Is Heterogeneous In Newborn Pigsmentioning

confidence: 99%

Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways

Xie¹,

Ostedgaard²,

Alaiwa³

et al. 2018

Annals ATS

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Cystic fibrosis (CF) lung disease is the major cause of morbidity and mortality in people with CF. Abnormal mucociliary transport has been the leading hypothesis for the underlying pathogenesis of CF airway disease. However, this has been difficult to investigate at very early time points. A porcine CF model, which recapitulates many features of CF disease in humans, enables studies to be performed in non-CF and CF pigs on the day that they are born. In newborn CF pigs, we found that under basal conditions, mucociliary transport rates in non-CF and CF pigs are similar. However, after cholinergic stimulation, which stimulates submucosal gland secretion, particles become stuck in the CF airways owing to a failure of mucus strands to release from submucosal glands. In this review, we summarize these recent discoveries and also discuss the morphology, composition, and function of mucins in the porcine lung.

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“…There are, however, different opinions regarding the continuity of the mucous layer. Some authors (Iravani & Van As, 1972;Van As & Webster, 1974) claim that the mucous layer is not continuous but consists of droplets and flakes. Others claim that it is continuous (Holma, 1971; Sturgess, 1977).…”

Section: Introductionmentioning

confidence: 99%

Clearance of Particles from the Human Tracheobronchial Tree

Camner

1980

Clinical Science

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The morphology of mucus in mammalian pulmonary airways

Cited by 30 publications

References 12 publications

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum

Mucociliary Transport in Healthy and Cystic Fibrosis Pig Airways

Clearance of Particles from the Human Tracheobronchial Tree

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